AI Article Synopsis
- The study investigates the relationship between skull growth and the development of papilledema in patients who underwent surgery for sagittal synostosis.
- Researchers analyzed occipitofrontal circumference (OFC) measurements at three time points, finding an initial decline in skull growth followed by stabilization in the long-term.
- Results indicated that smaller OFC measurements were significantly linked to a higher likelihood of developing papilledema, with specific thresholds identified for monitoring patients post-surgery.
Article Abstract
Objective: Stagnation of skull growth is correlated with papilledema in craniosynostosis. In this retrospective cohort study, we describe the postoperative skull growth after surgical correction for sagittal synostosis and its relation to the development of papilledema.
Methods: Patients with isolated sagittal synostosis at our center between 2005 and 2012 were included. Occipitofrontal circumference (OFC) was analyzed, at 3 time points (preoperative, 2 years postoperative, and last OFC measurement) and 3 phases (initial postoperative growth, long-term growth, and overall growth), and related to papilledema on fundoscopy.
Results: In total, 163 patients were included. The first time interval showed a decline in skull growth, with subsequent stabilization at long term. Papilledema occurred postoperatively in 10 patients. In these patients, the OFC at 2 years and at last follow-up (T3) were significantly smaller than in patients without papilledema. A larger OFC resulted in a decreased odds of developing papilledema at both postoperative time points (at T2 (OR = 0.40, p = 0.01) and at T3 (OR 0.29, p < 0.001)). Sensitivity and specificity analysis indicated that an OFC below 0.25 SD at T2 (sensitivity 90%, specificity 65%) and below 0.49 at T3 (sensitivity 100%, specificity 60%) are related to the occurrence of papilledema.
Conclusion: A small OFC is correlated with the occurrence of papilledema. A decline in OFC within 2 years postoperatively is common in sagittal synostosis and is acceptable up to a value of 0.25SD. Patients with an OFC at last follow-up of less than 0.5SD are at risk for developing papilledema.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968680 | PMC |
| http://dx.doi.org/10.1007/s00381-022-05629-x | DOI Listing |
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