Background: Currently, there is no consensus regarding the accuracy of magnetic resonance imaging (MRI) in the detection of acetabular chondral delamination (ACD) in patients with femoroacetabular impingement (FAI), and, correspondingly, the preoperative diagnosis of ACD remains challenging.
Hypothesis: It was hypothesized that MRI would have relatively high accuracy in detecting ACD in patients with FAI.
Study Design: Cohort study (diagnosis); Level of evidence, 2.
Methods: We retrospectively evaluated patients who attended the sports medicine clinic of our department and underwent arthroscopic surgery for the diagnosis of FAI between January 2018 and December 2020. All patients underwent preoperative 3.0-T MRI. ACD was evaluated by 2 raters on 3.0-T MRI scans, and interrater and intrarater reliability was assessed. Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of MRI for diagnosis of ACD were calculated, using arthroscopic surgery as the standard.
Results: A total of 233 patients (mean age, 37.4 years; 99 male and 134 female) were included in this study. The presence of ACD in 101 (43.3%) patients was confirmed during hip arthroscopy. The intraobserver reliability of both of the observers in detecting ACD using 3.0-T MRI scans was almost perfect (observer 1, kappa coefficient [κ] = 0.909 [95% CI, 0.854-0.964]; observer 2, κ = 0.937 [95% CI, 0.890-0.984]), and the interobserver reliability between the observers (κ = 0.801 [95% CI, 0.723-0.879]) was substantial. The overall sensitivity, specificity, PPV, and NPV of preoperative MRI to detect ACD were 83.7%, 82%, 74.2%, and 89.1%, respectively.
Conclusion: It was found that 3.0-T MRI had a relatively high sensitivity, specificity, PPV, and NPV for diagnosis of ACD in patients with FAI and could be a reliable method of diagnosing ACD preoperatively.
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http://dx.doi.org/10.1177/23259671221119225 | DOI Listing |
Med Phys
November 2024
Division of Physics and Biophysics, Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Background: Stereotactic MR-guided Adaptive Radiation Therapy (SMART) dose painting for hypoxia has potential to improve treatment outcomes, but clinical implementation on low-field MR-Linac faces substantial challenges due to dramatically lower signal-to-noise ratio (SNR) characteristics. While quantitative MRI and T mapping of hypoxia biomarkers show promise, T-to-noise ratio (TNR) optimization at low fields is paramount, particularly for the clinical implementation of oxygen-enhanced (OE)-MRI. The 3D Magnetization Prepared (2) Rapid Gradient Echo (MP2RAGE) sequence stands out for its ability to acquire homogeneous T-weighted contrast images with simultaneous T mapping.
View Article and Find Full Text PDFNeuroimage Clin
June 2024
Dementia Research Centre, University College London, 8-11 Queen Square, London WC1N 3AR, United Kingdom; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.
Introduction: Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns which group-average analyses fail to capture. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. Patient-specific atrophy patterns are measured objectively and summarised to index overall neurodegeneration (the 'total outlier count').
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2022
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Background: Localized regions of left-right image intensity asymmetry (LRIA) were incidentally observed on T -weighted (T -w) and T -weighted (T -w) diagnostic magnetic resonance imaging (MRI) images. Suspicion of herpes encephalitis resulted in unnecessary follow-up imaging. A nonbiological imaging artifact that can lead to diagnostic uncertainty was identified.
View Article and Find Full Text PDFSleep
October 2020
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Study Objectives: Sleep deprivation and circadian disruptions impair brain function and cognitive performance, but few studies have examined the effect of sleep inconsistency. Here, we investigated how inconsistent sleep duration and sleep timing between weekends (WE) and weekdays (WD) correlated with changes in behavior and brain function during task and at rest in 56 (30 female) healthy human participants.
Methods: WE-WD differences in sleep duration and sleep midpoint were calculated using 1-week actigraphy data.
Mol Pharm
November 2019
Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Designing effective and safe tuberculosis (TB) subunit vaccines for inhalation requires identification of appropriate antigens and adjuvants and definition of the specific areas to target in the lungs. Magnetic resonance imaging (MRI) enables high spatial resolution, but real-time anatomical and functional MRI of lungs is challenging. Here, we describe the design of a novel gadoteridol-loaded cationic adjuvant formulation 01 (CAF01) for MRI-guided vaccine delivery of the clinically tested TB subunit vaccine candidate H56/CAF01.
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