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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424991 | PMC |
| http://dx.doi.org/10.3389/fbioe.2022.983945 | DOI Listing |
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Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects.
Bioact Mater
February 2025
Department of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-4037, USA.
Large-gap nerve defects require nerve guide conduits (NGCs) for complete regeneration and muscle innervation. Many NGCs have been developed using various scaffold designs and tissue engineering strategies to promote axon regeneration. Still, most are tubular with inadequate pore sizes and lack surface cues for nutrient transport, cell attachment, and tissue infiltration.
View Article and Find Full Text PDFInnovating neurosurgical training: a comprehensive evaluation of a 3D-printed intraventricular neuroendoscopy simulator and systematic review of the literature.
Front Surg
November 2024
Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
Objective: The objective of this study was to develop and evaluate a low-cost 3D-printed simulator to improve the ability of neurosurgical residents to handle and coordinate endoscopes in performing technically demanding procedures such as neuroendoscopic removal of ventricular tumors or endoscopic third ventriculostomy (ETV).
Methods: The simulator was developed, printed in-house, and evaluated in a trial involving neurosurgery residents who performed ETV and intraventricular tumor resection tasks using it. Participants completed a questionnaire that assessed various aspects of the simulator's effectiveness, including anatomical visualization, procedural understanding, competency enhancement, and subjective impressions.
Optimising 3D printed medications for rare diseases: In-line mass uniformity testing in direct powder extrusion 3D printing.
Int J Pharm
January 2025
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom; FABRX Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, United Kingdom; FABRX Artificial Intelligence, Carretera de Escairón, 14, Currelos, O Saviñao CP 27543, Spain. Electronic address:
Biotinidase deficiency is a rare inherited disorder characterized by biotin metabolism issues, leading to neurological and cutaneous symptoms that can be alleviated through biotin administration. Three-dimensional (3D) printing (3DP) offers potential for personalized medicine production for rare diseases, due to its flexibility in designing dosage forms and controlling release profiles. For such point-of-care applications, rigorous quality control (QC) measures are essential to ensure precise dosing, optimal performance, and product safety, especially for low personalized doses in preclinical and clinical studies.
View Article and Find Full Text PDF3D Printing in ENT Training: Current State-of-the-Art and Perspectives.
Maedica (Bucur)
September 2024
Department of Otorhinolaryngology-Head and Neck Surgery, AHEPA University Hospital, Thessaloniki, Greece.
Objectives: Three-dimensional (3D) printing has been incorporated into medical research and numerous applications have been reported since its development in the 1980s. Ear, nose and throat (ENT) surgery is one of the fields that 3D printing is gaining increasing popularity, as it can contribute to surgical training, patient education and bioengineering. This article aims at providing an updated review of 3D printed models applications in improving ENT trainees' surgical skills.
View Article and Find Full Text PDFEfficacy of a saline wash plus vancomycin/tobramycin-doped PVA composite (PVA-VAN/TOB-P) in a mouse pouch infection model implanted with 3D-printed porous titanium cylinders.
Bone Joint Res
November 2024
Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopedic Research Laboratory, Southfield, Michigan, USA.
Aims: The efficacy of saline irrigation for treatment of implant-associated infections is limited in the presence of porous metallic implants. This study evaluated the therapeutic efficacy of antibiotic doped bioceramic (vancomycin/tobramycin-doped polyvinyl alcohol composite (PVA-VAN/TOB-P)) after saline wash in a mouse infection model implanted with titanium cylinders.
Methods: Air pouches created in female BalBc mice by subcutaneous injection of air.
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