Leaf rust of barley causes significant losses in crops of susceptible cultivars. Deploying host resistance is the most cost-effective and eco-sustainable strategy to protect the harvest. However, most known leaf rust resistance genes have been overcome by the pathogen due to the pathogen's evolution and adaptation. The discovery of novel sources of genetic resistance is vital to keep fighting against pathogen evolution. In this study, we investigated the genetic basis of resistance in barley breeding line GID 5779743 (GID) from ICARDA, found to carry high levels of seedling resistance to prevalent Australian pathotypes of . Multipathotype tests, genotyping, and marker-trait associations revealed that the resistance in GID is conferred by two independent genes. The first gene, , was detected using a linked CAPS marker and QTL analysis. The second gene was detected by QTL analysis and mapped to the same location as that of the locus on the telomeric region of chromosome 3HS. The segregating ratio in F (conforming to 9 resistant: 7 susceptible genetic ratio; > 0.8) and F (1 resistant: 8 segregating: 7 susceptible; > 0.19) generations of the GID × Gus population, when challenged with pathotype 5477 P- (virulent on and ) suggested the interaction of two genes in a complementary fashion. This study demonstrated that interacts with or an additional locus closely linked to (tentatively designated ) in GID to produce an incompatible response when challenged with a pathotype virulent on .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425046 | PMC |
| http://dx.doi.org/10.3389/fpls.2022.988322 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
REVEAL-CP: Selective Screening of Pediatric Patients for Aromatic L-Amino Acid Decarboxylase Deficiency with a Guthrie Card and Structural Modeling of One Index Case.
Genet Test Mol Biomarkers
January 2025
PTC Therapeutics Germany GmbH, Frankfurt, Germany.
The main objective of this prospective, multicenter study (REVEAL-CP) was to test children with cerebral palsy-like signs and symptoms for raised 3--methyldopa (3-OMD) blood levels, a biomarker for aromatic L-amino acid decarboxylase deficiency (AADCd). A secondary objective was to characterize the molecular basis for the defective aromatic L-amino acid decarboxylase (AADC) gene product. Patients were identified in pediatric secondary and tertiary care hospitals through database searches and personal communication.
View Article and Find Full Text PDFPhylogenetic relationships and genetic diversity of Tunisian maize landraces.
PLoS One
January 2025
Misión Biológica de Galicia (Spanish National Research Council, CSIC) Apdo 28, Pontevedra, Spain.
Based on history, maize was first introduced into Tunisia and northern Africa, at large, from the south of Spain. Several subsequent introductions were made from diverse origins, generating new landraces by recombination and selection for adaptation to arid environments. This study aimed to investigate the phylogenetic relationships among Tunisian maize landraces with possible sources of introduction from neighboring countries.
View Article and Find Full Text PDFEvolution of long scalp hair in humans.
Br J Dermatol
January 2025
Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
The ability to grow long scalp hair is a distinct human characteristic. It probably originally evolved to aid in cooling the sun-exposed head, although the genetic determinants of long hair are largely unknown. Despite ancestral variations in hair growth, long scalp hair is common to all extant human populations, which suggests its emergence before or concurrently with the emergence of anatomically modern humans (AMHs), approximately 300 000 years ago.
View Article and Find Full Text PDFReevaluating gender-affirming care: biological foundations, ethical dilemmas, and the complexities of gender dysphoria.
J Sex Marital Ther
January 2025
Department of Interdisciplinary Studies, University of South Florida, Tampa, FL, USA.
This paper critically examines the scientific and ethical underpinnings of gender-affirming care, particularly for minors. While major medical organizations endorse such interventions as medically necessary, the evidence supporting their long-term safety and efficacy remains limited. Research into hormonal, neuroanatomic, and genetic influences reveals a strong biological basis for gender identity, challenging social constructionist arguments.
View Article and Find Full Text PDFThe importance of preclinical models for cholangiocarcinoma drug discovery.
Expert Opin Drug Discov
January 2025
Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria.
Introduction: Biliary tract cancer (BTC) comprises a clinically diverse and genetically heterogeneous group of tumors along the intra- and extrahepatic biliary system (intrahepatic and extrahepatic cholangiocarcinoma) and gallbladder cancer with the common feature of a poor prognosis, despite increasing molecular knowledge of associated genetic aberrations and possible targeted therapies. Therefore, the search for even more precise and individualized therapies is ongoing and preclinical tumor models are central to the development of such new approaches.
Areas Covered: The models described in the current review include simple and advanced in vitro and in vivo models, including cell lines, 2D monolayer, spheroid and organoid cultures, 3D bioprinting, patient-derived xenografts, and more recently, machine-perfusion platform-based models of resected liver specimens.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!