AI Article Synopsis
- - Blood-based biomarkers, such as extracellular vesicle-associated miRNAs (EV-miRNAs) and serum TARC, are being studied for evaluating responses in classical Hodgkin lymphoma (cHL) alongside traditional imaging techniques like F-FDG-PET.
- - In a study involving 30 cHL patients, certain biomarkers demonstrated correlations with metabolic tumor volume (MTV) and dissemination, but not with tumor intensity features, indicating mixed levels of association.
- - The findings suggest that while blood-based biomarkers may complement PET imaging, further investigation is needed to integrate these markers into prognostic models effectively.
Article Abstract
Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422001 | PMC |
| http://dx.doi.org/10.1002/jha2.432 | DOI Listing |
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