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Eosinophilic Gastroenteritis with Ascites, Elevated Serum IgG4, and Hypereosinophilic Syndrome: A Manifestation of IgG4-related Disease?
Intern Med
August 2024
Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.
Article Synopsis
- A 76-year-old woman with ongoing diarrhea was hospitalized and found to have purpura, high eosinophil levels, and elevated IgG4 antibodies.
- CT scans showed large amounts of fluid in her abdomen and swelling in her intestines.
- Skin and gastrointestinal biopsies confirmed eosinophilic gastroenteritis and leukocytoclastic vasculitis but didn't meet criteria for IgG4-related disease, suggesting the connection between eosinophilic gastroenteritis and IgG4-related disease needs more research.
A diagnostic dilemma: distinguishing a sulfasalazine induced DRESS hypersensitivity syndrome from a CD30 + lymphoma in a young patient.
Int J Emerg Med
July 2024
Department of Emergency Medicine, ASZ Aalst, Aalst, Belgium.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity reaction characterized by cutaneous rash, lymphadenopathy, fever, eosinophilia, leukocytosis, and life-threatening organ dysfunctions. We describe the case of a 26 year old patient admitted to the Emergency Department for DRESS syndrome after sulfasalazine treatment for rheumatoid arthritis in the right knee. Whole body computer tomography showed multiple neck, chest, and abdominal lymphadenopathy with splenomegaly, massive ascites and severe hepatic cytolysis.
View Article and Find Full Text PDFEosinophilic mucus diseases.
Allergol Int
July 2024
Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan. Electronic address:
Article Synopsis
- * Disorders involving eosinophilic inflammation often lead to high-viscosity mucus accumulation, affecting conditions such as chronic rhinosinusitis and allergic asthma, and can result in severe tissue damage.
- * The review discusses the challenges posed by eosinophilic mucus, including its altered properties due to eosinophil aggregation, which contributes to persistent inflammation and potential organ damage.
Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis.
Am J Hum Genet
February 2024
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:
Eosinophilic esophagitis (EoE) is a rare atopic disorder associated with esophageal dysfunction, including difficulty swallowing, food impaction, and inflammation, that develops in a small subset of people with food allergies. Genome-wide association studies (GWASs) have identified 9 independent EoE risk loci reaching genome-wide significance (p < 5 × 10) and 27 additional loci of suggestive significance (5 × 10 < p < 1 × 10). In the current study, we perform linkage disequilibrium (LD) expansion of these loci to nominate a set of 531 variants that are potentially causal.
View Article and Find Full Text PDFMyeloid and lymphoid neoplasm with novel complex translocation: unusual case report with T-lymphoblastic lymphoma, myeloid hyperplasia, eosinophilia, basophilia, and t(1;8;10)( (p31;q24;q11.2).
J Hematop
March 2023
Pathology Department, College of Medicine and King Saud University Medical College, King Saud University, P.O Box2925, Riyadh, 11461, Kingdom of Saudi Arabia.
Myeloid and lymphoid neoplasms with eosinophilia (M/Ls-Eo) encompass heterogeneous but aggressive hematopoietic disorders triggered by fusion genes or mutations that typically lead to constitutive overexpression of tyrosine kinase. The occurrence of T-lymphoblastic lymphoma in the setting of M/Ls-Eo has been reported rarely in the literature. Herein, we present an unusual case of a 28-year-old male patient who presented with massive lymphadenopathy and T-lymphoblastic lymphoma in the lymph node occurring concurrently with myeloid hyperplasia, eosinophilia and basophilia in peripheral blood and bone marrow biopsy.
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