Introduction: The presence of silicone particles in breast implant capsules has been observed since the 1970s. Since then, little data has been published regarding the amount of silicone that is susceptible to migrate into the capsule. Quantifying the amount of silicone migration from the implant to the capsule could inform on the level of silicone exposure a patient with breast implants may experience in the short- or long-term. The objective of this study is to present a histological quantification methodology of the number of silicone particles present in breast implant capsules.
Materials And Methods: A prospective study was performed on capsule samples from patients requiring revision surgery. The slides were digitalized and analyzed with a viewer software. For each sample, we (1) manually counted each silicone particle, (2) measured the average particle size, (3) measured the capsule surface area, and (4) calculated the particle number density in each capsule sample. The average of all capsule samples' particle number densities was then compared to the total volume of the capsule to estimate the total number of silicone particles found within the capsule of each breast implant.
Results: Six capsules from six different patients were analyzed. Two capsules were from saline implants while four capsules were from silicone implants. All four silicone implant capsules contained between 352,928 and 9,002,235 silicone particles. The particle number density ranged from 20.5 to 683.5 particles per mm of capsule. The two saline-filled implant capsules were free of silicone particles. The average of all capsule samples' particle number densities was then compared to the total volume of the capsule to estimate the total number of silicone particles found within the capsule of each breast implant.
Conclusions: We describe a new and reproducible methodology to quantify realistically the silicone particles in the periprosthetic capsule of breast implants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.anplas.2022.08.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Soft Metalens for Broadband Ultrasonic Focusing through Aberration Layers.
Nat Commun
January 2025
Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Aberration layers (AL) often present significant energy transmission barriers in microwave engineering, electromagnetic waves, and medical ultrasound. However, achieving broadband ultrasonic focusing through aberration layers like the human skull using conventional materials such as metals and elastomers has proven challenging. In this study, we introduce an inverse phase encoding method employing tunable soft metalens to penetrate heterogeneous aberration layers.
View Article and Find Full Text PDFThe impact of active substance on the adhesiveness of medicated patches containing liquid additives.
Eur J Pharm Sci
December 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, Hallera av. 107, Gdansk 80-402, Poland.
Adhesiveness of dermal patches can be modified in the presence of active substances. The effect is more complex when liquid components are also present in the matrix. Commercial grade pressure sensitive adhesive (PSA) polyacrylates (three types) and silicones (two types) were used to prepare adhesive matrices and liquid additives were propylene glycol, polyoxyethylene glycol, isopropyl myristate, triacetin, triethyl citrate or low viscosity silicone oil.
View Article and Find Full Text PDFLevofloxacin-loaded silicone contact lenses materials for ocular drug delivery.
J Biomater Appl
December 2024
College of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Silicone contact lenses (SCL), as an emerging ocular drug delivery system, achieve controlled drug release. However, the existing drug loading methods have limitations such as low drug uptake, complicated operation process, poor welling rate and transmittance of the lens after drug loading. In this study, an effective microemulsion soaking method was proposed to increase the drug-loading capacity of silicone contact lenses.
View Article and Find Full Text PDFSilicone Breast Implants and Autoimmunity: A case report.
JPRAS Open
March 2025
Department of Biology, Universidad del Cauca, Popayán, Colombia.
The impact of breast implants on the immune system has been debated since their introduction in the 1960s, linking silicone to systemic autoimmune diseases. Recent studies have shown that silicone gel can migrate from the implant capsule, triggering immune responses by proliferating immune cells and releasing cytokines, affecting T-cell function. Silicone particles can induce the release of IL-1β and activate the NALP3 inflammasome and B cells, causing an imbalance in regulatory T cells, responder T cells, and Th17 cells.
View Article and Find Full Text PDFNanoparticle adhesion at liquid interfaces.
Soft Matter
December 2024
Department of Physics, Durham University, Durham, DH1 3LE, UK.
Nanoparticle adhesion at liquid interfaces plays an important role in drug delivery, dust removal, the adsorption of aerosols, and controlled self-assembly. However, quantitative measurements of capillary interactions at the nanoscale are challenging, with most existing results at the micrometre to millimetre scale. Here, we combine atomic force microscopy (AFM) and computational simulations to investigate the adhesion and removal of nanoparticles from liquid interfaces as a function of the particles' geometry and wettability.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!