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The Role of WNT5a and TGF-β1 in Airway Remodelling and Severe Asthma.
Allergy
January 2025
Department of Respiratory Sciences, College of Life Sciences, and NIHR Biomedical Research Centre (Respiratory Theme), Glenfield Hospital, Leicester, UK.
Background: Airway remodelling is a feature of severe asthma with airway epithelial damage observed frequently. We evaluated the role of WNT5a and TGF-β in asthmatic airway biopsies and in sputum and bronchial brushings assessed their role in remodelling.
Methods: WNT5a and TGF-β protein expression were assessed in the lamina propria epithelium of people with asthma (GINA 1-3, n-8 and GINA 4-5, n-14) and healthy subjects (n-9), alongside relevant remodelling markers.
In Asthma, Change Is the Only Constant.
Am J Respir Crit Care Med
December 2024
University of Southampton Faculty of Medicine, Clinical & Experimental Sciences, Southampton, United Kingdom of Great Britain and Northern Ireland;
Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success.
Breathe (Sheff)
October 2024
Division of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, UK.
Tuberculosis (TB) is a major global health threat and demands improved diagnostic and treatment monitoring methods. Conventional diagnostics, such as sputum smear microscopy and culture, are limited by slow results and low sensitivity, particularly in certain patient groups. Recent advances in biomarker research offer promising solutions in three key areas: risk of disease, diagnosis of active disease and monitoring of treatment response.
View Article and Find Full Text PDFType 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma.
Am J Respir Crit Care Med
November 2024
National Jewish Health, Denver, Colorado, United States;
Rationale: Corticosteroid-responsive type 2 (T2) inflammation underlies the T2-high asthma endotype. However, we hypothesized that type 1 (T1) inflammation, possibly related to viral infection, may also influence corticosteroid response.
Objectives: To determine the frequency and within-patient variability of T1-high, T2-high, and T1/T2-high asthma endotypes and whether virally influenced T1-high disease influences corticosteroid response in asthma.
Molecular characteristics of drug-susceptible Mycobacterium tuberculosis clinical isolates based on treatment duration.
Osong Public Health Res Perspect
October 2024
Division of Bacterial Disease Research, Center for Infectious Disease Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Background: In this study, we performed comparative genomic and transcriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB). The clinical isolates were categorized based on treatment duration: standard 6 months or >6 months.
Methods: Study participants were recruited from a 2016 to 2018 tuberculosis cohort, and clinical M.
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