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Rapid Preparation of Collagen/Red Blood Cell Membrane Tubes for Stenosis-Free Vascular Regeneration.
ACS Nano
January 2025
Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, PR China.
Extracellular matrix (ECM)-based small-diameter vascular grafts (SDVGs, inner diameter (ID) < 6 mm) hold great promise for clinical applications. However, existing ECM-based SDVGs suffer from limited donor availability, complex purification, high cost, and insufficient mechanical properties. SDVGs with ECM-like structure and function, and good mechanical properties were rapidly prepared by optimizing common materials and preparation, which can improve their clinical prospects.
View Article and Find Full Text PDFGold(I)-Catalyzed Nucleophilic Propargylations of Azinium Ions via Hydroxydihydroazine Intermediates.
Chemistry
January 2025
University of Nottingham, The GSK Carbon Neutral Laboratories for Sustainable Chemistry, Jubilee Campus, Triumph Road, NG7 2TU, Nottingham, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
The nucleophilic propargylation of azinium ions with a propargylboronate proceeds efficiently under gold(I) catalysis. A range of N-alkylated pyridinium, quinolinium, and pyrazinium ions undergo propargylation with good yields and high regioselectivities to give various functionalized 1,4-dihydropyridines, 1,2-dihydropyridines, 1,4-dihydroquinolines, 1,2-dihydroquinolines, and 4,5-dihydropyrazines. No allenylation side-products are observed.
View Article and Find Full Text PDFA Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model.
Int J Nanomedicine
January 2025
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.
Introduction: Cystic echinococcosis (CE), a chronic disabling parasitic zoonosis, poses a great threat to public health and livestock production and causes huge economic losses globally. The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side effects and insufficient immunity.
Purpose: This study aimed to employ a novel adjuvant consisting of a delivery system and an immune potentiator and assess its adjuvanticity to Eg95 antigen, thereby developing a safe and cost-effective novel vaccine against the disease.
Tibial Nerve injury in Medial Open Wedge-High Tibial Osteotomy - A Rare Complication with 14-Year Follow-Up.
J Orthop Case Rep
January 2025
Department of Orthopaedic Surgery, Murup Hospital, Changwon, South Korea.
Introduction: Medial open wedge-high tibial osteotomy (MOW-HTO) is a standard procedure for treating moderate varus arthritis in active adults. The reason for its popularity is having lesser complications than other types of HTO. However, it is not devoid of challenges.
View Article and Find Full Text PDFSulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition.
Biomater Sci
January 2025
Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
We are facing a shortage of new antibiotics to fight against increasingly resistant bacteria. As an alternative to conventional small molecule antibiotics, antimicrobial polymers (AMPs) have great potential. These polymers contain cationic and hydrophobic groups and disrupt bacterial cell membranes through a combination of electrostatic and hydrophobic interactions.
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