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Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melanocytes were observed in all Poodle skin hair bulbs, higher melanin content was observed in the darker Poodles. Several genes involved in melanogenesis were also identified as highly overexpressed in red Poodle skin. The most differentially expressed gene however was GPR22, which was highly expressed in red Poodle skin while unexpressed in white Poodle skin (log2 fold change in expression 6.1, P < 0.001). GPR22 is an orphan G-protein-coupled receptor normally expressed exclusively in the brain and heart. The SNNL1 retrocopy inserted 2.8 kb upstream of GPR22 and is likely disrupting regulation of the gene, resulting in atypical expression in the skin. Thus, we identify the SNNL1 insertion as a candidate variant for the CFA18 pheomelanin intensity locus in red Poodles.
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http://dx.doi.org/10.1093/g3journal/jkac227 | DOI Listing |
Vet Med Sci
January 2025
College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea.
Hamartoma is characterized by the abnormal proliferation of cells and tissues within the originating organ. Apocrine hamartoma (AH) affecting the skin, especially in the perianal area, has not yet been reported in dogs. A 7-year-old neutered male Poodle presented with multiple perianal papules and pruritus.
View Article and Find Full Text PDFOpen Vet J
October 2024
Dermatology Services for Dogs and Cats, Tokyo, Japan.
Background: Scales are composed of exfoliated keratinocytes and are frequently a secondary change, requiring the determination of the underlying cause. Consequently, making an appropriate differential diagnosis of scales and determining treatment necessity based on the results is crucial in dermatological practice.
Case Description: We present a 7-year-old, neutered male Toy Poodle examined at Myogadani Animal Hospital with chief complaints of exercise intolerance, unexplained weight gain, and dermatological signs, including symmetrical alopecia of the trunk.
Anim Genet
October 2024
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Open Vet J
March 2024
Departement of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Urolithiasis in dogs is a disorder of the urinary tract caused by the development of crystals. These crystals are composed of minerals such as phosphates, oxalates, urates, cystine, carbonates, and silica. It can be fatal if the diagnosis and treatment are inaccurate.
View Article and Find Full Text PDFJ Vet Med Sci
June 2024
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.
We describe here a case of canine mammary benign mixed tumor with sebaceous metaplasia in the right fifth mammary gland of an eight-year-old, intact female Poodle dog. Grossly, the mass was firm with off-white, poorly lobulated cut surfaces. Histologically, the luminal epithelial cells and myoepithelial cells proliferated with cartilage formation and focal squamous metaplasia.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!