Testicular cancer with androgen and estrogen secretion is classically associated with Leydig cell tumors. Rare case reports have described this finding in germ-cell tumors along with signs of androgen and estrogen excess including gynecomastia and infertility. We report the case of a 19-year-old male with a non-seminomatous testicular germ-cell tumor found to have hyperandrogenism, hyperestrogenism, and suppression of central sex hormones. Similar findings may be underreported in the literature, and males with suspected testicular malignancy should be appropriately screened for signs of androgen and/or estrogen excess so they can be offered appropriate monitoring and counseling.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419541 | PMC |
| http://dx.doi.org/10.7759/cureus.27396 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
d -Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI).
Gynecol Obstet Invest
September 2024
The Experts Group on Inositol in Basic and Clinical Research (EGOI), Rome, Italy.
Background:
Objectives: This perspective seeks to explore the mechanisms and functions of
Methods: A narrative review of all the relevant papers known to the authors was conducted.
Protective effects of iodine on rat prostate inflammation induced by sex hormones and on the DU145 prostate cancer cell line treated with TNF.
Mol Cell Endocrinol
July 2023
Departamento de Neurobiología Celular y Molecular. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, 76230, Querétaro, Mexico.
Molecular iodine (I) prevents oxidative stress and prostate hyperplasia induced by hyperandrogenism and reduces cell viability in prostate cancer cell lines. Here, we aimed to evaluate the protective effect of I and testosterone (T) on hyperestrogenism-induced prostate inflammation. Additionally, the effects of I and/or tumor necrosis factor (TNF) on cell viability and interleukin 6 (IL6) secretion were evaluated in a prostate cancer cell line (DU145).
View Article and Find Full Text PDFSevere intrahepatic cholestasis of pregnancy due to a Sertoli-Leydig cell tumour in a woman with polycystic ovary syndrome: a case report.
BMC Pregnancy Childbirth
November 2022
Women's hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, China.
Background: Intrahepatic cholestasis of pregnancy (ICP) is a common gestational complication characterized by pruritus and elevated bile acids, usually occurring in the third trimester when the serum estrogen and progesterone levels are highest. Hyperandrogenism during pregnancy is a pathological state that is mostly induced by polycystic ovary syndrome (PCOS) but rarely by concomitant androgen-secreting ovarian tumours. To date, no correlation has been drawn between ICP and hyperandrogenism.
View Article and Find Full Text PDFHyperandrogenism and Hyperestrogenism Secondary to Mixed Germ-Cell Testicular Tumor.
Cureus
July 2022
Catherine and Joseph Aresty Department of Urology, Keck School of Medicine of University of Southern California, Los Angeles, USA.
Testicular cancer with androgen and estrogen secretion is classically associated with Leydig cell tumors. Rare case reports have described this finding in germ-cell tumors along with signs of androgen and estrogen excess including gynecomastia and infertility. We report the case of a 19-year-old male with a non-seminomatous testicular germ-cell tumor found to have hyperandrogenism, hyperestrogenism, and suppression of central sex hormones.
View Article and Find Full Text PDFA Case Report of Hyperestrogenism in Prader-Willi Syndrome.
AACE Clin Case Rep
June 2021
Department of Medicine, McGill University, Division of Endocrinology, McGill University Health Center, Montreal, Quebec, Canada.
Objective: Prader-Willi syndrome (PWS) is associated with multiple endocrinopathies, including hypogonadism. The mechanism underlying hypogonadism in PWS is thought to be secondary to hypothalamic dysfunction, primary gonadal defect, or a combination of both. Here, we present a case of hyperestrogenism in PWS due to concomitant polycystic ovary syndrome (PCOS) and therapeutic considerations regarding hormone replacement therapy (HRT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!