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Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses.
Clin Exp Dermatol
April 2022
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Background: Neutrophilic dermatoses (ND) are a heterogeneous group of diseases, but can often have a relatively similar histological appearance.
Aim: To identify a combination of biomarkers allowing a better differentiation of ND types.
Methods: Biopsies were obtained from normal human skin (NS; n = 4), chronic plaque-type psoriasis (PsO; n = 7), paradoxical psoriasis (PP; n = 8), generalized pustular psoriasis (GPP; n = 9), subcorneal pustular dermatosis of Sneddon-Wilkinson (SPD; n = 3), acute generalized exanthematous pustulosis (AGEP; n = 3), hidradenitis suppurativa (HS; n = 7), Sweet syndrome (SS; n = 8) and pyoderma gangrenosum (PG; n = 8).
Acute generalised exanthematous pustulosis.
Australas J Dermatol
May 2012
Department of Clinical Immunology, Royal North Shore Hospital, PaLMS Immunorheumatology Laboratory and Northern Clinical School, Sydney University, Sydney, New South Wales, Australia.
Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is caused by drugs in >90% of cases. It is rare, with an incidence of 1-5 patients per million per year. The clinical manifestations are characterised by fever and the rapid appearance of disseminated sterile pustules 3-5 days after the commencement of treatment.
View Article and Find Full Text PDFLatent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.
EMBO J
April 2004
Department of Otolaryngology, Oregon Health & Science University, Portland, OR, USA.
Transforming growth factor beta1 (TGFbeta1), a potent keratinocyte growth inhibitor, has been shown to be overexpressed in keratinocytes in certain inflammatory skin diseases and has been thought to counteract the effects of other growth factors at the site of inflammation. Surprisingly, our transgenic mice expressing wild-type TGFbeta1 in the epidermis using a keratin 5 promoter (K5.TGFbeta1(wt)) developed inflammatory skin lesions, with gross appearance of psoriasis-like plaques, generalized scaly erythema, and Koebner's phenomenon.
View Article and Find Full Text PDFActinic superficial folliculitis.
J Eur Acad Dermatol Venereol
September 2003
Department of Dermatology, University of Heidelberg, Vossstr. 2, 69115 Heidelberg, Germany.
Actinic superficial folliculitis was first described in 1985, and since then only three reports have been published. Clinically and histopathologically this disease is very particular and has been suggested to be considered as an entity. We report on a 30-year-old man who presented with an extensive superficial follicular pustulosis on his back, shoulders and upper chest after exposure to intense heat and subsequent sweating on a sunny day.
View Article and Find Full Text PDFGeneralized pustular drug eruptions: confirmation by in vitro tests.
J Eur Acad Dermatol Venereol
January 1998
Dermatology Clinic, Sapir Medical Center, Meir General Hospital, Kfar Saba, Israel.
Background: Generalized pustular eruptions are characterized by acute onset of aseptic pustules in febrile patients with leukocytosis after exposure to the offending drug. They have been regarded as uncommon manifestations of adverse drug reactions. Until now few confirmation studies have been carried out.
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