Approximately 10% of community water systems in the United States experience a health-based violation of drinking water quality; however, recently allocated funds for improving United States water infrastructure ($50 billion) provide an opportunity to address these issues. The objective of this study was to examine environmental, operational, and sociodemographic drivers of spatiotemporal variability in drinking water quality violations using geospatial analysis and data analytics. Random forest modeling was used to evaluate drivers of these violations, including environmental (e.g., landcover, climate, geology), operational (e.g., water source, system size), and sociodemographic (social vulnerability, rurality) drivers. Results of random forest modeling show that drivers of violations vary by violation type. For example, arsenic and radionuclide violations are found mostly in the Southwest and Southcentral United States related to semiarid climate, whereas disinfection byproduct rule violations are found primarily in Southcentral United States related to system operations. Health-based violations are found primarily in small systems in rural and suburban settings. Understanding the drivers of water quality violations can help develop optimal approaches for addressing these issues to increase compliance in community water systems, particularly small systems in rural areas across the United States.
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http://dx.doi.org/10.1021/acs.est.1c08697 | DOI Listing |
J Med Chem
January 2025
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.
View Article and Find Full Text PDFJ Clin Invest
January 2025
Center for Inherited Myology Research, Virginia Commonwealth University, Richmond, United States of America.
Background: Myotonic dystrophy type 1 (DM1) is a multisystemic, CTG repeat expansion disorder characterized by a slow, progressive decline in skeletal muscle function. A biomarker correlating RNA mis-splicing, the core pathogenic disease mechanism, and muscle performance is crucial for assessing response to disease-modifying interventions. We evaluated the Myotonic Dystrophy Splice Index (SI), a composite RNA splicing biomarker incorporating 22 disease-specific events, as a potential biomarker of DM1 muscle weakness.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
January 2025
University of Kentucky, Lexington, KY, United States.
Background: Kentucky is within the top five leading states for breast mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiation therapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky.
Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry (KCR) for breast cancer patients diagnosed between 2010 and 2017, with follow-up through December 31, 2022.
Mol Cancer Res
January 2025
Fox Chase Cancer Center, Philadelphia, PA, United States.
Breast cancers of the IntClust-2 type, characterized by amplification of a small portion of chromosome 11, have a median survival of only five years. Several cancer-relevant genes occupy this portion of chromosome 11, and it is thought that overexpression of a combination of driver genes in this region is responsible for the poor outcome of women in this group. In this study we used a gene editing method to knock out, one by one, each of 198 genes that are located within the amplified region of chromosome 11 and determined how much each of these genes contributed to the survival of breast cancer cells.
View Article and Find Full Text PDFAm J Respir Crit Care Med
January 2025
Lanzhou University, Lanzhou, China;
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