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Systematic review on oncologic outcomes on adjuvant endovesical treatment for non-muscle invasive bladder cancer in patients with solid organ transplant.
World J Urol
December 2022
Department of Urology and Renal Transplantation, Urology, University Hospital La Conception, Aix-Marseille University, Marseille, France.
Article Synopsis
- * The review included 23 studies with 238 patients primarily from kidney transplants, showing that only 21% received any adjuvant treatment, and the overall disease-free survival was slightly higher with endovesical treatment compared to no treatment.
- * Although endovesical treatments like BCG are deemed safe for transplant patients on immunosuppressive therapy, the evidence regarding their effectiveness is limited, indicating they could be considered for treatment similar to the general population.
Endovesical Bacillus Calmette-Guérin for Nonmuscle Invasive Bladder Cancer in Kidney Transplant Recipients: Is It Safe and Efficacious?
Exp Clin Transplant
August 2022
From the Department of Urology, Kidney Transplantation and Andrology, Rangueil Hospital, Toulouse, France.
[A complex case of miliary pulmonary tuberculosis following intravesical BCG therapy].
Rev Med Liege
July 2020
Département d'Oncologie médicale, Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez, France.
Bladder cancer (urothelial carcinoma in 90 % of cases) is the most common neoplasia of the urinary tract. Superficial carcinoma represents 70-80 % of bladder cancers. The treatment of these tumours includes, after transuretral resection, intravesical Bacillus Calmette-Guerin (BCG) instillation therapy.
View Article and Find Full Text PDFMiliary tuberculosis induced by intravesical instillation of bacillus Calmette-Guérin.
Radiologia (Engl Ed)
April 2020
Servicio de Radiodiagnóstico, Hospital Clínico Universitario de Valladolid, Valladolid, España.
The intravesical instillation of bacillus Calmette-Guérin (BCG) is an efficacious complementary treatment for superficial bladder cancer after transurethral resection. This treatment delays progression, decreases the probability that the patient will have to undergo cystectomy in the future, and improves survival; it is generally efficacious and well tolerated. Among the most common local complications are irritative symptoms, hematuria, local genitourinary infection.
View Article and Find Full Text PDFThe challenges of Bacillus of Calmette-Guerin (BCG) therapy for high risk non muscle invasive bladder cancer treatment in older patients.
J Geriatr Oncol
September 2018
Department of Urology, "Agostino Gemelli" Academic Hospital Foundation, IRCCS, Catholic University School of Medicine, Rome, Italy.
Objectives: To evaluate the efficacy and safety of a tailored endovesical immunotherapy protocol with biweekly BCG for elderly Patients with high risk non muscle invasive bladder cancer (HG-NMIBC).
Materials And Methods: We retrospectively evaluated data from 200 patients older than 80 years newly diagnosed with HG-NMIBC: 100 (group 1) with multiple comorbidities (WHO PS 2-3, ASA score ≥3, Charlson Comorbidity index ≥3, GFR<60 mL/min) were treated with BCG induction course administered biweekly; 100 (group 2) with statistically significant better conditions were treated with standard weekly BCG therapy. After the induction treatment disease-free patients underwent to at least one year of BCG maintenance therapy.
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