How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531301 | PMC |
| http://dx.doi.org/10.15252/embj.2022112250 | DOI Listing |
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