A new and enantioselective total synthesis of the diterpenoid (+)-mutilin is described. Following a Claisen rearrangement approach to construct the 6,9-bicycle, a transannular [2+2] photocycloaddition and the ensuing ring-opening reaction were implemented to forge the characteristic 5-6-8 propellane-like skeleton. Subsequent late-stage alkylations and reduction completed the synthesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.2c06934 | DOI Listing |
Publication Analysis
Top Keywords
total synthesis
8
transannular [2+2]
8
synthesis +-mutilin
4
+-mutilin transannular
4
[2+2] cycloaddition/fragmentation
4
cycloaddition/fragmentation approach
4
approach enantioselective
4
enantioselective total
4
synthesis diterpenoid
4
diterpenoid +-mutilin
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!