AI Article Synopsis
- - The study analyzed pregnancy outcomes in women aged 20-45 who conceived using oocyte donation (102 women) compared to a control group of spontaneously conceived pregnancies (306 women) to determine if complications stemmed from the oocyte donation itself or other factors.
- - Results showed that women using donor oocytes had a higher average age (35.13 years) and experienced significantly higher rates of pregnancy complications, such as pregnancy-induced hypertension (33.33% vs. 7.18%) and gestational diabetes (34.31% vs. 9.47%).
- - The findings suggest that oocyte donation increases risks for miscarriage, hypertensive disorders, and gestational diabetes mellitus, indicating it should be regarded as an
Article Abstract
Background: Oocyte donation has facilitated couples to achieve pregnancy in conditions like diminished ovarian reserve, premature ovarian failure, and inheritable disorders. However, it is unclear whether pregnancy complications are due to oocyte donation per se or due to confounding factors such as maternal age or the allogenic fetus. In this retrospective comparative cohort, an attempt was made to evaluate and compare multiple obstetric and perinatal outcomes.
Methods: The present study comprised all women in the age range of 20-45 years who conceived from oocyte donation (n=102) between 1/12/2011 to 30/09/2017. Control group consisted of spontaneous conception cases (n=306) in ratio of 1:3 with no previous medical or surgery comorbidity. Obstetric and perinatal outcomes were compared between two groups.
Results: Mean maternal age was significantly higher in the donor oocyte IVF group (group 1; 35.13 years) as compared to spontaneous conception group (group 2; 31.75 years). Parity between the two groups was comparable. Pregnancy induced hypertension (PIH) was seen in 33.33% of cases in group 1 as compared to 7.18% in group 2. Moreover, gestational diabetes mellitus was seen in 34.31% of cases in group 1 as compared to 9.47% in group 2 (p=0.001). By the same token, there was significant difference in perinatal outcomes between the two groups.
Conclusion: Oocyte donation should be treated as an independent risk factor for miscarriage, hypertensive disorder, and gestational diabetes mellitus in pregnancy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363908 | PMC |
| http://dx.doi.org/10.18502/jri.v23i2.8994 | DOI Listing |
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