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| http://dx.doi.org/10.26633/RPSP.2022.62 | DOI Listing |
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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients.
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Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Background: Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on HER2 as a single diagnostic marker to predict the efficacy of anti-HER2 drugs is insufficient.
View Article and Find Full Text PDFLate-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study.
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Department of Epidemiology and Health Statistics and West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
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Simulated retail food environments: A literature review of systems science approaches to advance equity in access to healthy diets.
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Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Rensselaer, NY, USA.
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View Article and Find Full Text PDFDriving force analysis and multi-scenario simulation of landscape ecological risk in the Jianghan Plain, China.
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Hubei Key Laboratory of Biologic Resources Protection and Utilization, Hubei Minzu University, Enshi, 445000, Hubei Province, China.
As a key food production base, land use changes in the Jianghan Plain (JHP) significantly affect the surface landscape structure and ecological risks, posing challenges to food security. Assessing the ecological risk of the JHP, identifying its drivers, and predicting the risk trends under different scenarios can provide strategic support for ecological risk management and safeguarding food security in the JHP. In this study, the landscape ecological risk (LER) index was constructed by integrating landscape indices from 2000 to 2020, firstly analyzing its spatiotemporal characteristics, subsequently identifying the key influencing factors by using the GeoDetector model, and finally, simulating the risk changes under the four scenarios by using the Markov-PLUS model.
View Article and Find Full Text PDFThe environmental impact of inhalers: a framework for sustainable prescription practices in Spain.
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Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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