AI Article Synopsis
- Diabetes mellitus (DM) doubles the risk of developing endometrial cancer (EC) and is linked to a worse prognosis due to factors like high glucose levels that promote cancer cell growth.
- This review explores the connections between DM and EC, highlighting biological mechanisms such as insulin resistance, inflammation, and obesity that may explain this relationship.
- It suggests that early treatment with metformin could become a promising option for managing EC in patients with DM, pointing towards the potential for new prevention and therapy strategies that focus on glucose metabolism.
Article Abstract
The presence of diabetes mellitus (DM) has a critical influence on the occurrence and development of endometrial cancer (EC) and is associated with a poor prognosis. Patients with DM are twice as likely to progress to EC, probably because a high-glucose environment contributes to the growth and invasiveness of EC cells. In this review, we focus on the etiological links between DM and EC and provide an overview of potential biological mechanisms that may account for this relationship, including hyperglycemia, insulin resistance, hyperinsulinemia, glycolysis, chronic inflammation, obesity, and activation of signaling pathways involved in EC. Furthermore, we discuss the pharmacological management of EC associated with DM. Early treatment with metformin is expected to be an effective adjuvant alternative for EC in the future. This knowledge is important for further opening up preventive and therapeutic strategies for EC by targeting glucose metabolism.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410665 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000030299 | DOI Listing |
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