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Randomized Trial of Enhanced Versus Standard Navigation to Promote Timely Initiation of Adjuvant Radiotherapy for Head and Neck Cancer.
JCO Oncol Pract
January 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA.
Purpose: National Comprehensive Cancer Network Guidelines recommend initiating postoperative radiation therapy (PORT) within 6 weeks of surgery for patients with head and neck squamous cell carcinoma (HNSCC), but delays affect 50% of patients, disproportionately burden minoritized groups, and contribute to worse oncologic outcomes. This trial evaluates the efficacy of Navigation for Disparities and Untimely Radiation thErapy (NDURE), an enhanced navigation-based intervention, relative to usual care (UC) patient navigation for starting timely PORT.
Methods: Adults with locally advanced HNSCC planning to undergo surgery and PORT were randomly assigned 1:1 to standard multidisciplinary head and neck oncology care and either NDURE, a multilevel navigation-based intervention to enhance key processes of care and overcome barriers to timely PORT, or UC, which consisted of standard patient navigation.
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis.
Hum Cell
January 2025
Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore, India.
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with oral squamous cell carcinoma (OSCC), highlighting the importance of understanding tumor-node cross-talk for effective prognostic and therapeutic interventions. Herein, we describe the development and characterization of primary lymph node stromal cells (LNSCs, N = 14) from nodes of metastatic and non-metastatic OSCC patients. Primary cultures were established by the explant method from positive (N + ; N = 2), and negative nodes (N0; N = 4) of the metastatic patients (N = 3) as well as negative (N0; N = 8) nodes from non-metastatic (N = 4) patients.
View Article and Find Full Text PDFHistopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer.
Pathol Int
January 2025
Department of Pathology, Tohoku University Hospital, Sendai, Japan.
Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH).
View Article and Find Full Text PDFCoexistence of Hodgkin Lymphoma and Squamous Cell Carcinoma of the Tongue: A Case Report and Literature Review.
Cureus
December 2024
Pathology, Prince Sultan Military Medical City, Riyadh, SAU.
We report an unusual case of a 39-year-old male patient with a previous history of treated classical Hodgkin lymphoma, presenting with tongue ulcer and left ear pain who was subsequently diagnosed with invasive squamous cell carcinoma of the oropharynx. This case highlights the importance of vigilance in patients with a history of lymphoma and the potential for the development of secondary malignancies. We discuss the clinical, radiological, and pathological findings and emphasize the need for close monitoring and early intervention in such cases.
View Article and Find Full Text PDFManagement of choroidal/ciliary body metastasis in the era of targeted cancer therapy.
Front Oncol
December 2024
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, United States.
Introduction: Choroidal metastases from systemic malignancies are the most common intraocular malignancies in adults. External beam radiation (EBR) has historically been first-line therapy for metastatic tumors to the choroid. However, good responses have been described with newer targeted biologics.
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