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Advances in moyamoya disease: pathogenesis, diagnosis, and therapeutic interventions.
MedComm (2020)
February 2025
Department of Neurosurgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China.
Moyamoya disease (MMD) is a type of cerebrovascular disease characterized by occlusion of the distal end of the internal carotid artery and the formation of collateral blood vessels. Over the past 20 years, the landscape of research on MMD has significantly transformed. In this review, we provide insights into the pathogenesis, diagnosis, and therapeutic interventions in MMD.
View Article and Find Full Text PDFNano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy.
Mol Pharm
January 2025
College of Life Science and Technology, Changchun University of Science and Technology, 7089 Satellite Road, Changchun 130022, China.
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy and chemotherapy, often lack specificity, leading to collateral damage to normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, and elevated ATP levels factors that collectively promote tumor growth and metastasis.
View Article and Find Full Text PDFIdentification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study.
JMIR Form Res
January 2025
Center on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, United States.
Background: Despite increasing fatal stimulant poisoning in the United States, little is understood about the mechanism of death. The psychological autopsy (PA) has long been used to distinguish the manner of death in equivocal cases, including opioid overdose, but has not been used to explicitly explore stimulant mortality.
Objective: We aimed to develop and implement a large PA study to identify antecedents of fatal stimulant poisoning, seeking to maximize data gathering and ethical interactions during the collateral interviews.
Staged surgery for the treatment of carotid aneurysm.
J Surg Case Rep
January 2025
Department of Vascular Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.
Extracranial carotid artery aneurysm (ECAA) is a relatively rare vascular lesion of the neck, and is usually found incidentally and is usually asymptomatic. Surgery is currently the first choice for symptomatic or growing ECAA, including open resection of the entire aneurysm, with or without arterial replacement and insertion of grafts. Ischemic stroke is the most serious complication after resection of ECAA.
View Article and Find Full Text PDFThe Impact of Domestic Violence and Sexual Assault on Family Dynamics and Child Development: A Comprehensive Review.
Turk Arch Pediatr
January 2025
Department of Forensic Medicine, İstanbul Health and Technology University Faculty of Medicine, İstanbul, Türkiye.
This review synthesizes current research on domestic violence and sexual assault, focusing on their short-term and long-term effects on family dynamics, particularly on the development and well-being of children and adolescents. The article employs a curated body of literature, including surveys, reviews, program evaluations, and international health reports, to elucidate the direct and collateral damage caused by such trauma within families. The review critically examines the intersecting consequences of abuse, including immediate psychological distress and long-term socio-economic and educational disruptions for affected youths.
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