An organocatalytic, highly diastereo- and enantioselective [6 + 2]-cycloaddition of 3-methide-3-pyrroles with 2-vinylindoles has been developed. This BINOL phosphoric acid-catalyzed reaction utilizes pyrrole-3-carbinols as precursors for the in situ generation of 3-methide-3-pyrroles to access densely substituted cyclopenta[]pyrroles bearing three contiguous stereogenic centers as single diastereomers in good yields with excellent enantioselectivity.
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College of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun, P. R. China.
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