AI Article Synopsis
- NAFLD is a growing public health issue worldwide, particularly affecting children, and metformin, typically used for type 2 diabetes, shows promising results in treating it.
- A systematic literature review was conducted using major medical databases to gather existing research on metformin's effects on children's NAFLD.
- While metformin is effective, further investigation into its mechanisms, potential for combined treatments, and monitoring of side effects is necessary for better management of the disease.
Article Abstract
Introduction: The increased economic and social burdens for NAFLD worldwide make treating such a disease a significant public health issue. Metformin, a kind of insulin sensitizer generally used to treat type 2 diabetes, has been recently found to have efficacy on children's NAFLD in various areas such as glucolipid metabolism, intestinal bacterial metabolism, oxidative stress, and anti-inflammatory response. This article aims to provide an overview of the possible mechanisms of NAFLD in children and the potential therapeutic application of metformin.
Areas Covered: The Cochrane Library, PubMed, Scopus, and EMBASE database was systematically searched on 12 April 2022, using the keywords metformin; non-alcoholic fatty liver disease; and children to identify similar studies. An additional search for recently published research was performed in June 2020.
Expert Opinion: Although metformin has been proved to have an excellent therapeutic effect on children's NAFLD; we can still explore its potential impacts and mechanisms from different angles, such as combined medication. At the same time, we should also pay attention to its side effects.
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Source |
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| http://dx.doi.org/10.1080/17474124.2022.2118112 | DOI Listing |
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