A novel furo[3,2-]pyridine-based AIE photosensitizer for specific imaging and photodynamic ablation of Gram-positive bacteria.

Chem Commun (Camb)

Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.

Published: September 2022

An Rh-catalyzed tandem reaction was performed to construct an AIE-active furo[2,3-]pyridine-based photosensitizer, named LIQ-TF. LIQ-TF showed near-infrared emission with high quantum yield, and high O and ˙OH generation efficiency, and could be used for specific imaging and photodynamic ablation of Gram-positive bacteria and , showing great potential for combating multiple drug-resistant bacteria.

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http://dx.doi.org/10.1039/d2cc04084kDOI Listing

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