A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from was used successfully to remove type B blood group antigens enzymatically from human kidneys using normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364487 | PMC |
| http://dx.doi.org/10.1093/bjs/znac293 | DOI Listing |
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