A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including ,-dialkyl aniline and indole derivatives.
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| http://dx.doi.org/10.1021/acs.orglett.2c01897 | DOI Listing |
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