As the levels of plastic use in global society have increased, it has become crucial to regulate plastics of all sizes including both microplastics (MPs) and nanoplastics (NPs). Here, the published literature on the current laws passed by the US Congress and regulations developed by various federal agencies such as the US Environmental Protection Agency and the US Food and Drug Administration (FDA) that could be used to regulate MPs and NPs have been reviewed and analyzed. Statutes such as the Clean Water Act, the Safe Drinking Water Act, the Toxic Substances Control Act (TSCA), the Resource Conservation and Recovery Act, and the Clean Air Act can all be used to address plastic pollution. These statutes have not been invoked for MP and NP waste in water or air. The Federal Food, Drug, and Cosmetic Act provides guidance on how the FDA should evaluate plastics use in food, food packaging, cosmetics, drug packaging, and medical devices. The FDA has recommended that acceptable levels of ingestible contaminant from recycled plastic are less than 1.5 µg/person/day, which is 476 000 times less than the possible ingested daily dose. Plastic regulation is present at the state level. States have banned plastic bags, and several cities have banned plastic straws. California is the only state beginning to focus on monitoring MPs in drinking water. The future of MP regulation in the USA should use TSCA to test the safety of plastics. The other statutes need to include MPs in their definitions. For the FDA, MPs should be redefined as contaminants-allowing tolerances to be set for MPs in food and beverages. Through minor changes in how MPs are classified, it is possible to begin to use the current statutes to understand and begin to minimize the possible effects of MPs on human health and the environment. Integr Environ Assess Manag 2023;19:474-488. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/ieam.4678 | DOI Listing |
Chem Eng J
July 2024
Program in Environmental and Polymer Engineering, Graduate School of INHA University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Korea.
Microplastics (MPs) have been detected in various environmental matrices, drinking water, and food, and their presence is an ecological and human health concern. Most research on MPs has focused solely on their detection and analysis. However, sample pretreatment methods are critical for accurate MP analysis and must be properly established.
View Article and Find Full Text PDFPNAS Nexus
January 2025
Systems Engineering, College of Engineering, Cornell University, Ithaca, NY 14853, USA.
Methods are needed to mitigate microplastic (MP) pollution to minimize their harm to the environment and human health. Given the ability of polypeptides to adsorb strongly to materials of micro- or nanometer size, plastic-binding peptides (PBPs) could help create bio-based tools for detecting, filtering, or degrading MNP pollution. However, the development of such tools is prevented by the lack of PBPs.
View Article and Find Full Text PDFEMBO Mol Med
January 2025
Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.
The exposome is the measure of all the exposures of an individual in a lifetime and how those exposures relate to health. Exposomics is the emerging field of research to measure and study the totality of the exposome. Exposomics can assist with molecular medicine by furthering our understanding of how the exposome influences cellular and molecular processes such as gene expression, epigenetic modifications, metabolic pathways, and immune responses.
View Article and Find Full Text PDFCurr Top Dev Biol
January 2025
Université de Strasbourg, IGBMC UMR 7104, Illkirch, France; CNRS, UMR 7104, Illkirch, France; Inserm, UMR-S 1258, Illkirch, France; IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France. Electronic address:
In mammals, differentiation of germ cells is crucial for sexual reproduction, involving complex signaling pathways and environmental cues defined by the somatic cells of the gonads. This review examines the long-standing model positing that all-trans retinoic acid (ATRA) acts as a meiosis-inducing substance (MIS) in the fetal ovary by inducing expression of STRA8 in female germ cells, while CYP26B1 serves as a meiosis-preventing substance (MPS) in the fetal testis by degrading ATRA and preventing STRA8 expression in the male germ cells until postnatal development. Recent genetic studies in the mouse challenge this paradigm, revealing that meiosis initiation in female germ cells can occur independently of ATRA signaling, with key roles played by other intrinsic factors like DAZL and DMRT1, and extrinsic signals such as BMPs and vitamin C.
View Article and Find Full Text PDFEnviron Pollut
January 2025
Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410013, PR China. Electronic address:
Microplastics (MPs) are becoming a significant environmental and public health concern because they are present in freshwater and marine environments and are ingested by living organisms. Cholestatic liver disease (CLD) is closely related to intestinal homeostasis, but there are no data investigating the effects of MPs on CLD. In this study, we used Mdr2 mice (a model of CLD) to investigate the effects of polystyrene microplastics (PS-MPs, 0.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!