Three new compounds, (8)-2,2,7,7-tetramethyl-8-hydroxymethyl-6-indanone-(2,3-b)-2-pyran-9-O--d-glucopyranoside (), (7,8)-2,2,7-trimethyl-7-hydroxymethyl-8-hydroxy-2,7,8,9-tetrahydro-6-naphtho-(2,3-b)-pyran-10-O--d-glucopyranoside (), 1-deoxy-1-(3,4-dihydro-7-methyl-2,3-dioxo-1(2)-quinoxalinyl)pentitol-6-carboxylic acid (3), as well as six known compounds (), were obtained. Their structures were determined by spectroscopy and comparison with NMR data of related compounds. Absolute configurations were determined by ECD spectroscopy. The hepatoprotective effects of these compounds were investigated on HepG2 and LO2 cells lines; compounds , , and displayed moderate activity.
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http://dx.doi.org/10.1080/10286020.2022.2115367 | DOI Listing |
Front Pharmacol
December 2024
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
The seed of (Ser.) C.B.
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December 2024
School of Clinical Medical, Chengdu Medical College, Chengdu, China.
Apigenin (CHO, API) is a natural flavonoid widely found in vegetables, fruits, and plants such as celery, oranges, and chamomile. In recent years, API has attracted considerable attention as a dietary supplement due to its low toxicity, non-mutagenic properties and remarkable therapeutic efficacy in various diseases. In particular, evidence from a large number of preclinical studies suggests that API has promising effects in the prevention and treatment of a variety of liver diseases, including multifactorial liver injury, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, liver fibrosis and liver cancer.
View Article and Find Full Text PDFCell Biochem Biophys
January 2025
Faculty of Medicine, Department of Histology and Embryology, Eskişehir Osmangazi University, Eskişehir, Türkiye.
Silymarin, a flavonoid complex isolated from Silybum marianum, possesses various biological properties, including antioxidant, anti-inflammatory, anti-glycation, and hepatoprotective effects. In the present study, we investigated the effects of silymarin on the SPC212 human mesothelioma cell line. MTT and neutral red assays were performed to examine the cytotoxic effects of silymarin.
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December 2024
Instituto Multidisciplinar em Saúde - Campus Anísio Teixeira, Universidade Federal da Bahia, Vitória da Conquista, Bahia 45029-094, Brazil; Programa de Pós-Graduação em Biociências, Vitória da Conquista, Bahia 45029-094, Brazil; Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas - PPGM-SBFis. Vitória da Conquista, Bahia 45029-094, Brazil. Electronic address:
Cisplatin (CP) is an antineoplastic drug associated with various cytotoxic adverse effects, including hepatotoxicity. Exercise training may offer hepatoprotection by improving redox status. This study compared the effects of light-intensity continuous training (LICT), moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT) on CP-induced hepatotoxicity in female Wistar rats.
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December 2024
Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, India. Electronic address:
Methyl donors regulate the one-carbon metabolism and have significant potential to reduce oxidative stress and inflammation. Therefore, this study aims to investigate the protective effect of methyl donors against CCl-induced liver fibrosis. Liver fibrosis was induced in male Sprague Dawley rats using CCl at a dose of 1 ml/kg (twice a week for a 4-week, via intraperitoneal route).
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