AI Article Synopsis
- The ability to adjust to changes in oxygen levels is crucial for survival, influencing both evolutionary biology and medical applications.
- This study reviews how different species, including humans, have adapted to low oxygen conditions and how these adaptations relate to health issues like high-altitude sickness, heart and lung diseases, and sleep apnea.
- The integration of multi-omics research helps to highlight connections between these adaptations and offers new insights for both fundamental and clinical studies on hypoxia.
Article Abstract
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400701 | PMC |
| http://dx.doi.org/10.3389/fphys.2022.885295 | DOI Listing |
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