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Comprehensive Analysis of Paraneoplastic Neurologic Syndrome and PNS-CARE Diagnostic Criteria in Clinical Practice.
Neurol Neuroimmunol Neuroinflamm
December 2024
From the Departments of Neurology (H.Z.-F., M.R., P.G., A.Z., E.P.F., S.J.P., A.M., D.D.) and Laboratory Medicine and Pathology (M.R., P.G., A.Z., E.P.F., S.J.P., A.M., D.D.), Mayo Clinic, Rochester, MN; and Department of Neurology (S.S.), Vanderbilt University, Nashville, TN.
Article Synopsis
- The 2021 PNS-CARE score, an updated diagnostic tool for Paraneoplastic Neurologic Syndrome (PNS), was assessed for its effectiveness and application in a cohort of patients at the Mayo Clinic.
- A retrospective study involving 484 patients suspected of having PNS found that 212 were confirmed to have the syndrome, with common autoantibodies including PCA1, KLHL11, and CRMP5.
- The newer criteria showed high sensitivity and specificity (93% and 100% respectively), outperforming the previous criteria from 2004, which had lower sensitivity (67%) but similar specificity (99%).
Article Synopsis
- "Burned-out" testicular tumor is a rare condition where a metastatic germ cell tumor shows no signs in the testicle because the primary tumor has regressed on its own.
- The case discussed involves a patient with an embryonal germ cell carcinoma that led to a severe tumor thrombus in the inferior vena cava and malignant pulmonary embolism.
- FDG PET/CT imaging was crucial in identifying the extent and seriousness of the tumor's impact on the patient's health.
Testicular tumors are one of the most commonly observed malignancies among men. An aggressive and rare subtype of the disease, testicular choriocarcinoma, has a worse prognosis due to the tendency of early hematogenous spread to multiple organs and advanced symptoms at presentation time. Characteristic features of choriocarcinoma include elevated beta human chorionic gonadotropin (β-hCG) in a young male with testicular mass.
View Article and Find Full Text PDFParaneoplastic Kelch-like protein 11 antibody-associated cerebellar and limbic encephalitis caused by metastatic "burned-out" seminoma - A scar(r)y phenomenon.
J Neuroimmunol
May 2023
Department of Neurology, Semmelweis University, Budapest, Hungary.
Introduction: The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. "burned-out").
View Article and Find Full Text PDF[Burned-out testicular germ cell tumors: a clinicopathological analysis of three cases].
Zhonghua Bing Li Xue Za Zhi
April 2023
Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University Medical College, Shanghai 200025, China.
To investigate the clinicopathological features and possible mechanisms of burned-out testicular germ cell tumors. The clinical and imaging data, histology and immunophenotypic characteristics of three cases of burned-out testicular germ cell tumors diagnosed at the Ruijin Hospital, Medical College of the Shanghai Jiaotong University, from 2016 to 2020 were retrospectively analyzed. The relevant literature was reviewed.
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