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Covalently crosslinked carboxymethyl chitosan beads containing SiO and ionic polymer for efficient adsorptive removal of methylene blue.
Int J Biol Macromol
January 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, PR China. Electronic address:
The carboxymethyl chitosan (CMCS)-based porous beads are still criticized for their limited number of binding sites, which impairs their efficacy in removing aqueous pollutants. To overcome this challenge, this work introduces the production of covalently crosslinked CMCS-based beads containing SiO and poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS). The porous composite beads not only possess remarkable stability under acidic conditions, but also have abundant active binding sites for adsorption.
View Article and Find Full Text PDFShared chemoresistance genes in ESCC and cervical Cancer: Insights from pharmacogenomics and Mendelian randomization.
Int Immunopharmacol
January 2025
Department of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China; Department of Pathology, School of Basic Medicine, Central South University, Changsha City, Hunan Province, China; Ultrapathology (Biomedical Electron Microscopy) Center, Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China; FuRong Laboratory, Changsha City, Hunan Province, China. Electronic address:
Background: Neoadjuvant chemotherapy, particularly the use of platinum-based compounds and taxanes, is pivotal in the treatment of epithelial-derived tumors, such as cervical cancer and esophageal squamous cell carcinoma (ESCC); however, resistance remains a significant challenge. Utilizing Mendelian randomization (MR) with pharmacogenomics offers a novel approach to understanding the genetic underpinnings of drug responses, thereby aiding in personalized treatment.
Methods: Single-cell RNA sequencing (scRNA-seq) analysis revealed a shared cellular subpopulation of CD8 + T effector memory (CD8 + TEM) cells that are pivotal in mediating chemotherapy resistance in ESCC and cervical cancer.
Co-delivery of astaxanthin using positive synergistic effect from biomaterials: From structural design to functional regulation.
Food Chem
December 2024
College of Food Science and Technology, Shanghai Ocean University, Shanghai, China; Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, Shanghai, China; National Experimental Teaching Demonstration Center for Food Science and Engineering, Shanghai Ocean University, Shanghai, China. Electronic address:
The powerful antioxidant properties of astaxanthin (AST) face two significant challenges: low water solubility and poor chemical stability. To overcome them, extensive research and development efforts have been directed toward creating effective delivery systems. Among them, the positive synergistic effect between biomaterials can be used to refine the design of delivery systems.
View Article and Find Full Text PDFThe specific extraction of glabridin from licorice residues using molecular imprinting technique.
Food Chem
December 2024
School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China. Electronic address:
The large-scale production of glycyrrhizic acid inevitably generates a large amount of licorice residues waste, which contains a wealth of active ingredients, especially glabridin, a natural preservative. However, traditional extraction methods for glabridin are often limited by bottlenecks such as time-consuming, inefficient, and insufficient specificity. To overcome these challenges, this study innovatively introduced 2-phenylimidazole as a functional monomer by computer simulations and successfully developed magnetic molecularly imprinted polymers (MMIPs) for glabridin.
View Article and Find Full Text PDFCAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment.
Curr Pharm Biotechnol
January 2025
Department of Pharmacology, School of Pharmacy & Technology Management, SVKM's NMIMS Deemed to-be University, Shirpur - 425405, India.
The world's one of the major causes of death are cancer. Cancer is still a complex disease over the years that needs to be cured. Traditional cytotoxic approaches, although they have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy and low efficiency of cancer cells.
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