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Oral aspirin or low dose of intravenous lysine acetylsalicylate in ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
J Cardiovasc Med (Hagerstown)
July 2021
Division of Cardiology.
Aim: To compare the pharmacodynamic effect of an oral loading dose of 'noncoated' ASA 300 mg vs. an intravenous bolus injection of lysine acetylsalicylate 150 mg in patients with STEMI undergoing pPCI.
Methods: This was a prospective single-center, open label, pharmacodynamic study, including nonconsecutive patients presenting at our catheterization laboratory with STEMI undergoing pPCI and not receiving ASA within the previous 7 days.
Efficacy of mesotherapy using drugs versus normal saline solution in chronic spinal pain: a retrospective study.
Int J Rehabil Res
June 2017
aDepartment of Physical Medicine and Rehabilitation, Teaching Hospital Foundation 'Agostino Gemelli', Catholic University of Sacred Heart bDepartment of Physical Medicine and Rehabilitation, Clinical Sciences and Translational Medicine, Tor Vergata University, Rome cDepartment of Physical and Rehabilitative Medicine, Scientific Institute of Lissone MB, Istituti Clinici Scientifici Maugeri, IRCCS, Lissone MB, Italy dDepartment of Physical Therapy and Sports Medicine, University of Craiova, Craiova, Romania.
Mesotherapy, or intradermal therapy, is a therapeutic approach that is gaining popularity, but there is still a significant lack of information on its mechanisms of action or the pharmacokinetics of the therapeutic regimens. This retrospective study on 220 records compared the short-term and long-term effects of mesotherapy using a mixture of drugs versus normal saline solution in the treatment of patients with chronic spinal pain (CSP). At the end of treatment, outcome measures showed a significant improvement (P<0.
View Article and Find Full Text PDFStudy of non-opioid analgesics tolerance in young and adult rats.
Georgian Med News
May 2008
Department of Neurophysiology, Beritashvili Institute of Physiology, Tbilisi, Georgia.
It was demonstrated that systemic injections of metamizol and lysine-acetylsalicylate (LASA) induce inhibition of tail-flick reflex and hot-plate responses and their repeated administration leads to the development of tolerance. However, it has not been established whether these effects can be elicited by other non-steroidal anti-inflammatory drugs (NSAIDs). In this study the authors used other commonly applied analgesics--analgine, ketorolac, xefocam, which are the representatives of the three diverse groups of NSAIDs.
View Article and Find Full Text PDFAspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver.
Folia Med Cracov
January 2008
Zakład Biologii Rozwoju Człowieka, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Intraperitoneal injections of lysine acetylsalicylate (L-ASA, aspirin) in a dose of 10 mg during 5 consecutive days to BALB/c and B10.PL mice increased the concentration of endogenous hydrogen sulfide in their livers. The rise of hydrogen sulfur levels was shown also in brains of BALB/c females and B10.
View Article and Find Full Text PDFThe local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Anesth Analg
April 2007
Department of Pharmacology, Gülhane Academy of Medicine, Etlik, Ankara, Turkey.
Background: While many preclinical models detect the analgesic activity of nonsteroidal antiinflammatory drugs (NSAIDs), the radiant heat tail-flick response has repeatedly been insensitive to this class of drugs. As the tail-flick test involves nociceptive processing at spinal circuits with supraspinal modulation, it seems reasonable to assume that the NSAIDs should not modify strong nociceptive stimuli, since the primary site of action of NSAIDs is likely to be in the periphery.
Methods: We injected 3-300 mug of diclofenac, dipyrone, ketorolac, lysine acetyl salicylate, and sodium salicylate intradermally into mice tails and evaluated the tail-flick response to radiant heat.
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