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Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome.
iScience
January 2025
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Mutations in the human genes encoding the endothelin ligand-receptor pair and cause Waardenburg-Shah syndrome (WS4), which includes congenital hearing impairment. The current explanation for auditory dysfunction is defective migration of neural crest-derived melanocytes to the inner ear. We explored the role of endothelin signaling in auditory development in mice using neural crest-specific and placode-specific mutation plus related genetic resources.
View Article and Find Full Text PDFInvestigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity.
Heliyon
January 2025
Department of Cardiothoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, 224002, China.
Research has demonstrated that POU3F4 is integral to various cancers, in addition to its significance in inner ear development, pancreatic differentiation, as well as neural stem cell differentiation. Nevertheless, comprehensive pan-cancer analyses focusing on POU3F4 remain limited. This study aims to assess the prognostic value of POU3F4 in thirty-three cancers and explore its immune-related functions.
View Article and Find Full Text PDFNot all who meander are lost: migrating sea lamprey follow river thalwegs to facilitate safe and efficient passage upstream.
J Exp Biol
January 2025
Michigan State University, Department of Fisheries and Wildlife, East Lansing, MI, USA.
Efficient navigation is crucial for the reproductive success of many migratory species, often driven by competing pressures to conserve energy and reduce predation risk. Little is known about how non-homing species achieve this balance. We show that sea lamprey (Petromyzon marinus), an ancient extant vertebrate, uses persistent patterns in hydro-geomorphology to quickly and efficiently navigate through complex ecosystems.
View Article and Find Full Text PDFA OHCs-Targeted Strategy for PEDF Delivery in Noise-Induced Hearing Loss.
Adv Healthc Mater
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, P. R. China.
Noise-induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage to sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery to the inner ear. This study applied a retro-auricular round window membrane (RWM) method to bypass the BLB, enabling the transport of macromolecular proteins into the inner ear.
View Article and Find Full Text PDFOvercoming Shifting Baselines: Paleo-Behaviour Reveals Industrial Revolution as Tipping Point.
Glob Chang Biol
January 2025
School of Science, Auckland University of Technology, Auckland, New Zealand.
Human activities have significantly altered coastal ecosystems worldwide. The phenomenon of shifting baselines syndrome (SBS) complicates our understanding of these changes, masking the true scale of human impacts. This study investigates the long-term ecological effects of anthropogenic activities on New Zealand's coastal ecosystems over 800 years using fish otolith microchemical profiling and dynamic time warping across an entire stock unit.
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