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A Nested Case-Control Study of the Relationship between Salivary Inflammatory Mediators, Periodontal Parameters, and Preterm Birth in a Chinese Population. | LitMetric

AI Article Synopsis

  • The study investigates the link between salivary inflammatory markers and periodontal health as predictors of preterm birth (PTB) in pregnant women.
  • Researchers enrolled 26 women who experienced PTB and 104 controls with full-term births, measuring various periodontal indices and salivary inflammatory mediators.
  • Results suggest that higher bleeding index and levels of prostaglandin E2 in saliva during specific weeks of pregnancy may indicate an increased risk of PTB, although further research with a larger group is needed to confirm these findings.*

Article Abstract

Background: To explore whether salivary inflammatory mediators and periodontal indices at different gestational stages can be taken as indicators of preterm birth (PTB).

Methods: This nested case-control study enrolled systemically healthy pregnant women at 9 to 36 weeks of gestation. Periodontal indices were measured at the enrollment date, and interleukin-1 (IL-1), IL-6, tumor necrosis factor (TNF-), prostaglandin E2 (PGE2), and 8-hydroxy-deoxyguanosine (8-OHdG) in the saliva were determined by enzyme-linked immunosorbent assay (ELISA). The birth outcome was recorded.

Results: PTB occurred in 26 women. A total of 104 matched women with full-term birth (FTB) were used as controls. The PTB women enrolled at 24-28 gestational weeks displayed a significantly greater bleeding index (BI), probing pocket depth (PD), PD ≥ 4 mm sites (%), saliva-TNF-, and saliva-PGE2 ( < 0.05). BI and PGE2 in the saliva were found to be positively associated with PTB (OR = 4.79, = 0.048, 95%CI = 1.014 to 22.628; OR = 1.07, = 0.04, 95%CI = 1.004 to 1.135, respectively). The areas under the receiver operating characteristic curve (ROC) of BI and saliva-PGE2 were 0.82 and 0.78, respectively, and that of the combined detection was 0.91, which was larger than either marker alone, although the differences were not significant ( > 0.05).

Conclusions: The combination of BI and PGE2 in saliva at 24-28 gestational weeks could be a predictor of PTB in asymptomatic women. However, the results should be further explored with larger sample size.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410790PMC
http://dx.doi.org/10.1155/2022/8629680DOI Listing

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