AI Article Synopsis
- Human respiratory cancers, including lung and oral cancers, contribute significantly to cancer-related deaths, largely due to tumor metastasis.
- Fascin-1 is a key protein involved in tumor cell movement by remodeling the actin cytoskeleton, and its overexpression in tumors indicates a link to tumor growth and invasion.
- This study aims to clarify the role of fascin-1 in respiratory cancers, suggesting it could be a valuable biomarker and therapeutic target.
Article Abstract
Human cancer statistics report that respiratory related cancers such as lung, laryngeal, oral and nasopharyngeal cancers account for a large proportion of tumors, and tumor metastasis remains the major reason for patient death. The metastasis of tumor cells requires actin cytoskeleton remodeling, in which fascin-1 plays an important role. Fascin-1 can cross-link F-actin microfilaments into bundles and form finger-like cell protrusions. Some studies have shown that fascin-1 is overexpressed in human tumors and is associated with tumor growth, migration and invasion. The role of fascin-1 in respiratory related cancers is not very clear. The main purpose of this study was to provide an updated literature review on the role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers. These studies suggested that fascin-1 can serve as an emerging biomarker and potential therapeutic target, and has attracted widespread attention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404296 | PMC |
| http://dx.doi.org/10.3389/fonc.2022.948110 | DOI Listing |
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