Extracting relational triples from unstructured medical texts can provide a basis for the construction of large-scale medical knowledge graphs. The cascade binary pointer tagging network (CBPTN) shows excellent performance in the joint entity and relation extraction, so we try to explore its effectiveness in the joint entity and relation extraction of Chinese medical texts. In this paper, we propose two models based on the CBPTN: CBPTN with conditional layer normalization (Cas-CLN) and biaffine transformation-based CBPTN with multi-head selection (BTCAMS). Cas-CLN uses the CBPTN to decode the head entity and relation-tail entity successively and utilizes conditional layer normalization to enhance the connection between the two steps. BTCAMS detects all possible entities in a sentence by using the CBPTN and then determines the relation between each entity pair through biaffine transformation. We test the performance of the two models on two Chinese medical datasets: CMeIE and CEMRDS. The experimental results prove the effectiveness of the two models. Compared with the baseline CasREL, the F1 value of Cas-CLN and BTCAMS on the test data of CMeIE improved by 1.01 and 2.13%; on the test data of CEMRDS, the F1 value improved by 1.99 and 0.68%.
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http://dx.doi.org/10.3934/mbe.2022498 | DOI Listing |
FEBS Open Bio
January 2025
Sunny BioDiscovery Inc., Santa Paula, CA, USA.
Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory medication used to treat multiple sclerosis (MS) and psoriasis. Its skin sensitization property precludes its topical use, which is unfortunate for the treatment of psoriasis. Isosorbide di-(methyl fumarate) (IDMF), a novel derivative of DMF, was synthesized to circumvent this adverse reaction and unlock the potential of topical delivery, which could be useful for treating psoriasis in the subpopulation of psoriatic MS patients, as well as in the general population.
View Article and Find Full Text PDFActa Pharmacol Sin
January 2025
Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Gout is a systemic metabolic disorder caused by elevated uric acid (UA) levels, affecting over 1% of the population. The most common complication of gout is gouty arthritis (GA), characterized by swelling, pain or tenderness in peripheral joints or bursae, which can lead to the formation of tophi. At present, western medicines like colchicine, febuxostat and allopurinol are the primary treatment strategy to alleviate pain and prevent flare-ups in patients with GA, but they have significant side effects and increased mortality risks.
View Article and Find Full Text PDFCureus
December 2024
Orthopedics and Traumatology, Unidade Local de Saúde de Viseu Dão-Lafões, Viseu, PRT.
Idiopathic transient osteoporosis of the hip (ITOH) is a rare and self-limiting condition of unknown origin, typically responding well to conservative treatment. It is characterized by progressive pain, claudication, and osteoporosis of the femoral head, while the joint line remains preserved. Early clinical and radiological findings can be misinterpreted as aseptic necrosis, infection, or neoplastic processes, making careful exclusion of these conditions essential.
View Article and Find Full Text PDFSports Med
January 2025
Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed.
Objective: We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset.
Introduction: The impact of being diagnosed with a life-threatening illness may influence preferences to participate in treatment decisions. The objective of this analysis was to identify factors that are associated with sarcoma patients wanting to take a more active or passive role.
Methods: Data was obtained as part of a nationwide multicenter study (PROSa) aiming to investigate the structure and quality of medical care of sarcoma patients in Germany and their determinants.
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