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Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water. | LitMetric
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Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water.

Jeannette Jansen Elke Beyreuther Daniel García-Calderón Leonhard Karsch Jan Knoll Jörg Pawelke Michael Schürer Joao Seco

Radiother Oncol

Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Physics and Astronomy, Ruprecht-Karls-University, Heidelberg, Germany. Electronic address:

Published: October 2022

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.

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http://dx.doi.org/10.1016/j.radonc.2022.08.024DOI Listing

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