AI Article Synopsis
- Intravesical instillation is a method used to deliver drugs directly into the bladder for treating urological issues, but it has challenges like pain and frequent clinic visits.
- Researchers have developed a new biodegradable intravesical device made of PCL microcapsules and PDS sutures, which is easy to insert and remains in the bladder for up to four weeks.
- The device allows for long-term drug release of medications like lidocaine and resiquimod, and a cost-effectiveness analysis shows it's a better option compared to traditional treatment methods.
Article Abstract
Intravesical instillation is an efficient drug delivery route for the local treatment of various urological conditions. Nevertheless, intravesical instillation is associated with several challenges, including pain, urological infection, and frequent clinic visits for catheterization; these difficulties support the need for a simple and easy intravesical drug delivery platform. Here, we propose a novel biodegradable intravesical device capable of long-term, local drug delivery without a retrieval procedure. The intravesical device is composed of drug encapsulating biodegradable polycaprolactone (PCL) microcapsules and connected by a bioabsorbable Polydioxanone (PDS) suture with NdFeB magnets in the end. The device is easily inserted into the bladder and forms a 'ring' shape optimized for maximal mechanical stability as informed by finite element analysis. In this study, inserted devices were retained in a swine model for 4 weeks. Using this device, we evaluated the system's capacity for delivery of lidocaine and resiquimod and demonstrated prolonged drug release. Moreover, a cost-effectiveness analysis supports device implementation compared to the standard of care. Our data support that this device can be a versatile drug delivery platform for urologic medications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485746 | PMC |
| http://dx.doi.org/10.1016/j.biomaterials.2022.121703 | DOI Listing |
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