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Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals' aging processes are diverse. Phenotypic age acceleration (PhenoAgeAccel) is a validated biological age measure incorporating chronological age and biomarkers from blood samples commonly used in clinical practice that can better reflect aging-related morbidity and mortality risk. The heterogeneity of age-related decline is not random, as environmental exposures can promote or impede healthy aging.
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Center for Chronic Disease Research and Policy, University of Chicago Medicine, Chicago, IL, USA.
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Department of Health & Human Services, University of Michigan, Dearborn, Michigan.
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