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T-cell-based therapies for treating relapsed or refractory mantle cell lymphoma.
Hematology Am Soc Hematol Educ Program
December 2024
Lymphoma Service, Division of Hematologic Malignancies, New York, NY.
While targeted therapies such as Bruton's tyrosine kinase and BCL2 inhibitors have fundamentally changed the treatment of mantle cell lymphoma (MCL), not all patients respond to these therapies, and responses are finite and can be fleeting, especially with high-risk MCL. As patients progress through successive therapies, the clinical course is characterized by shortening response times,1 frequent disease acceleration, and limited survival outcomes. Recently, the sensitivity of MCL to novel immune-based therapies is being realized with favorable results, as chimeric antigen receptor-modified T cells and bispecific T-cell-engaging antibodies are being investigated and implemented into practice for patients.
View Article and Find Full Text PDFMultiple pathogen infections accompanied with ocular pathologies in a patient with high-titer Anti-IFN-γ autoantibodies: a case report.
BMC Infect Dis
November 2024
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, P.R. China.
Article Synopsis
- Patients with high levels of anti-IFN-γ autoantibodies (AIGAs) often suffer from infections caused by intracellular pathogens, as well as associated immune disorders.
- A 53-year-old woman with high titers of AIGAs was hospitalized due to a mass, leading to diagnoses of multiple infections including Talaromyces marneffei and Aspergillus flavus.
- Despite extensive treatment including antifungal and anti-NTM therapies, the patient experienced rapid recurrence of infections and developed ocular problems, which were managed with eye drops and lubricants.
Reprint of: Scientific statement from the French neurovascular and cardiac societies for improved detection of atrial fibrillation after ischaemic stroke and transient ischaemic attack.
Rev Neurol (Paris)
December 2024
Hôpitaux de l'est parisien (Saint-Antoine-Tenon), AP-HP, Sorbonne Université, Inserm ICAN 1166, 184, Faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
Atrial fibrillation (AF) is the primary cause of ischaemic stroke and transient ischaemic attack (TIA). AF is associated with a high risk of recurrence, which can be reduced using optimal prevention strategies, mainly anticoagulant therapy. The availability of effective prophylaxis justifies the need for a significant, coordinated and thorough transdisciplinary effort to screen for AF associated with stroke.
View Article and Find Full Text PDFDetecting the presence of different Retzius periodicities at the population level from repetitive linear enamel hypoplasia among Lufengpithecus lufengensis and Pongo pygmaeus.
Am J Biol Anthropol
December 2024
Kunming Natural History Museum of Zoology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Objectives: Reconstruction of life histories for fossil and living primates draws on rate of enamel layering, termed Retzius periodicity (RP in days) expressed as surface perikymata, during dental crown formation. Disclosure of RP through thin sectioning is destructive; consequently, sample sizes are inadequate to detect the range of RPs present in discrete taxa. We propose an additional method to detect RPs at the population level based on twice-yearly average recurrence of linear enamel hypoplasia (rLEH) in apes shown by prior studies.
View Article and Find Full Text PDFCombined analysis of a serum mRNA/miRNA marker signature and CA 19-9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study.
United European Gastroenterol J
October 2024
Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps-University and University Hospital Marburg, Marburg, Germany.
Background And Aims: Timely and accurate detection of tumor recurrence in pancreatic ductal adenocarcinoma (PDAC) patients is an urgent and unmet medical need. This study aimed to develop a noninvasive molecular diagnostic procedure for the detection of recurrence after PDAC resection based on quantification of circulating mRNA and miRNA biomarkers in serum samples.
Methods: In a multicentric study, serum samples from a total of 146 patients were prospectively collected after resection.
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