AI Article Synopsis

  • Ulcerative colitis (UC) is a chronic disease whose incidence is rising globally, and the study aimed to compare the effects of two treatments, Infliximab (IFX) and Adalimumab (ADA), on secondary health outcomes in UC patients.
  • In this one-year observational study, 238 patients were analyzed using various quality of life measurement tools, and statistical tests were employed to evaluate health-related quality of life (HRQoL) factors.
  • The results indicated no significant differences in secondary health outcomes between patients treated with IFX and those treated with ADA, while education level and presence of other chronic diseases were found to significantly impact HRQoL.

Article Abstract

Background: Ulcerative colitis (UC) is a chronic global disease, and its incidence and prevalence are increasing worldwide.

Objective: Our objective was to compare the secondary outcome of treatment with Infliximab (IFX) and Adalimumab (ADA) in the UC patients.

Methods: This was a one-year prospective observational study of moderate- to -severe UC patients treated with ADA or IFX. Patients' secondary health outcomes were measured using the EQ-5D 3L, EQ-VAS, and IBDQ-9 tools. T-test, Mann-Whitney, chi-square, and Fisher's exact tests were used to compare health-related quality of life (HRQoL) among UC patients. HRQoL predictor variables were identified by multivariate linear regression and multivariate logistic regression.

Results: A total of 238 UC patients (patients taking IFX: 78, patients taking ADA: 160) with a mean age of 37.66 and a mean disease duration of 9.29 years were enrolled. The EQ-5D index, EQ-VAS, and IBDQ-9 scores of patients taking IFX were 0.65, 55.93 and, 37.42, respectively. Similarly, patients taking ADA were 0.68, 59.27 and, 36.61, respectively. The highest problem reports were in P/D: 86.1% and A/D: 73.5%. The main independent predictors of HRQoL were: education over 12 years (β = 0.054 [EQ-5D index], β = 13.63 [EQ-VAS], OR: 0.28 [MO], OR: 0.07 [SC]), education between 6-12 years (β = 11.23 [EQ-VAS]), and having "other chronic diseases" (β = -0.074 [EQ-5D index], β = -5.29 [IBDQ-9], OR: 2.84 [UA], OR: 3.80 [A/D]).

Conclusion: There was no significant difference between the effect of ADA and IFX on secondary health outcomes in patients with moderate-to-severe UC.

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Source
http://dx.doi.org/10.2174/1574886317666220526153518DOI Listing

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