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Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19? | LitMetric

AI Article Synopsis

  • SARS-CoV-2 has led to over 550 million infections and around 6.4 million deaths by July 2022, causing significant global health challenges.
  • The virus continues to evolve, reducing the effectiveness of current vaccines and treatments, particularly against the Omicron BA.4 and BA.5 variants.
  • To combat these ongoing issues, it is crucial to deepen our understanding of how the virus causes disease and to develop more specific treatment options.

Article Abstract

SARS-CoV-2 has caused devastating effects with over 550 million infections by July 2022 and approximately 6.4 million deaths [1]. Societal and economic impacts will reverberate for years, with continuous evolution of SARS-CoV-2 as it persistently spreads through the human population as exemplified by reduced activity of vaccines and monoclonals against Omicron BA.4 or BA.5 subvariants [2]. A greater understanding of pathogenesis and more tailored therapeutic approaches are therefore essential.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411729PMC
http://dx.doi.org/10.1183/13993003.01521-2022DOI Listing

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