One undescribed C terpenoid, calomacroquinoic acid; four undescribed diterpenes, 5α,6α-epoxy-7α-hydroxyferruginol, 15-ethoxysugiol, 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol, and ethyl 7,8-secoabieta-11,14-dioxo-7-ate; two compounds isolated from Nature for the first time, 6β,7α-dihydroxyferruginol and 12-O-methyltaxochinon; and six known compounds were successfully identified from the bark of Taiwan incense cedar Calocedrus formosana. Structures of all isolates were elucidated by physical data (appearance, ultraviolet, infrared, specific rotation, and X-ray) and spectroscopic data (1D and 2D nuclear magnetic resonance, and high-resolution electron ionization mass spectrometry). The biosynthetic pathway of calomacroquinoic acid is also described in the current study. Nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells was inhibited by 6,7-dehydroferruginol, 7α,11-dihydroxy-12-methoxy-8,11,13-abietriene, and trans-communic acid. Altogether, the bark of C. formosana possessed several potential natural therapeutics against inflammation-related neuronal diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2022.113347 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.
Nat Prod Res
December 2024
Interdisciplinary Centre for Innovations in Biotechnology and Neuroscience, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka.
Cinnamon is a spice that is renowned for its several medicinal and cosmetic benefits. The research study examined the essential oil content, antioxidant, and anti-inflammatory properties of seven species native to Sri Lanka. Cinnamon bark and leaf samples were used to extract essential oils, methanol, and hexane.
View Article and Find Full Text PDF2'-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1.
Int J Mol Sci
December 2024
School of Life Science, National Taiwan Normal University, Taipei 117, Taiwan.
2'-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of , has anti-inflammatory and anti-tumor activities. In this study, we explored whether HCA preconditioning could protect the heart against ischemia/reperfusion (I/R)-induced oxidative injury through cytosolic Bcl-2-associated athanogene 3 (BAG3) upregulation. In vivo HCA preconditioning was performed intraperitoneally in adult male Wistar rats (50 mg/kg body weight) three times/week for 2 weeks before cardiac I/R injury.
View Article and Find Full Text PDFGallic Acid Alleviates Glucolipotoxicity-Induced Nephropathy by miR-709-NFE2L2 Pathway in db/db Mice on a High-Fat Diet.
J Agric Food Chem
October 2024
Department of Health Industry Technology Management, Chung Shan Medical University, Taichung 402, Taiwan.
Background: Type 2 diabetes mellitus (T2DM) has become a major global issue, with diabetic nephropathy (DN) ranking as one of its most serious complications. The involvement of microRNAs (miRNAs) in the progression of T2DM and DN is an area of active research, yet the molecular mechanisms remain only partially elucidated. Gallic acid (GA), a naturally occurring polyphenolic compound found in various plants such as bearberry leaves, pomegranate root bark, tea leaves, and oak bark, has demonstrated antioxidant properties that may offer therapeutic benefits in DN.
View Article and Find Full Text PDFEffective removal of chromium by adsorption using Delonix regia bark derived activated carbon from aqueous solution: a sustainable approach.
Environ Geochem Health
July 2024
Department of Civil Engineering, Faculty of Engineering, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore, Tamil Nadu, 641021, India.
This study introduces a new biosorbent derived from Delonix regia bark-activated carbon to efficiently remove Chromium Cr(VI) metal ions from aqueous systems. The biosorbent was synthesized from the bark powder of the plant species and chemically activated with phosphoric acid. The biosorbent was characterized using FTIR, SEM, and BET to determine its functional properties and structural morphology.
View Article and Find Full Text PDFAbietane Diterpenoids from the Bark of and Their Antifungal Activities against Wood Decay Fungi.
Plants (Basel)
April 2024
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
Phytochemical investigation of the bark of led to the isolation of five new abietane diterpenoids, 5--12-hydroxy-6--5,6-secoabieta-8,11,13-trien-7,5-olide (), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (), together with one known abietane diterpenoid, obtuanhydride (). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 μg/mL, compounds , and inhibited antifungal activities against wood decay fungi activity by 18.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!