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Raha syrup attenuates the morphine withdrawal-induced locomotor sensitisation by increasing the cerebrospinal fluid serotonin in rats receiving the opium tincture maintenance treatment.
Nat Prod Res
June 2024
Research Centre of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Morphine withdrawal increases locomotor sensitisation, relapse and impair regulation of serotonin system. We evaluated the effectiveness of Raha syrup on the cerebrospinal fluid (CSF) serotonin levels following locomotor sensitisation in morphine-withdrawn rats receiving the opium tincture (OT). Morphine withdrawal rats gavaged daily with OT and Raha syrup (for 30 days) and then challenged with morphine and evaluated for locomotor activity and CSF serotonin levels before morphine challenge and 2 weeks after cessation of treatment.
View Article and Find Full Text PDFAn insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine.
Biomed Pharmacother
February 2024
Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth. (kratom). It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain.
View Article and Find Full Text PDFLooking Back, Moving Forward in Pain Medicine.
Cureus
September 2023
Pain Medicine, Paolo Procacci Foundation, Rome, ITA.
Pain is an ancient medical complaint and a clinical riddle that has never been entirely solved. Looking back into history was the springboard to a look into the future of pain medicine. This article was based on a series of presentations given in a recent congress (May 2023) and represents the research, views, and opinions of the authors.
View Article and Find Full Text PDFUnearthed opium: development of a UHPLC-MS/MS method for the determination of alkaloids in Daunian vessels.
Front Chem
July 2023
Department of Chemistry, Sapienza University of Rome, Rome, Italy.
The analysis of organic residue in ancient vessels to investigate early-age civilization habits is an important archeological application that needs advanced analytical methods. However, these procedures should meet inherent requisites such as low sampling invasiveness and high sensitivity for trace analysis. This study deals with the development of advanced analytical methods for the detection of opium alkaloids in ceramic vessels and its first application to the study of Daunian pots dating back to the VIII-IV sec BC.
View Article and Find Full Text PDFOpium alkaloids, biosynthesis, pharmacology and association with cancer occurrence.
Open Biol
May 2023
School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India.
L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (100 different benzylisoquinoline alkaloids (BIAs)). L-tyrosine serves as a precursor of several specific metabolites like BIAs.
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