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Frequency and consequences of immune checkpoint inhibitor-associated inflammatory changes in different organs: an autopsy study over 13-years.
Mod Pathol
December 2024
Department of Pathology and Molecular Pathology, University Hospital of Zurich, Switzerland; University of Zurich, Switzerland.
While immune checkpoint inhibitors (ICIs) have revolutionized modern oncology, they are also associated with immune-related adverse events (irAEs). Previous histopathological descriptions of organ-related inflammatory changes do not consider systemic effects of ICIs, because of an absence of comprehensive autopsy studies. We performed a retrospective study on 42 whole-body autopsies of patients treated with ICIs from January 2011 to March 2024 to determine frequency, organ distribution and morphology of ICIs-associated inflammatory changes as well as their clinical relevance.
View Article and Find Full Text PDFImpact of 18FDG PET/CT on Clinical Management, Cost Effectiveness, and Radiation Exposure in Newly Diagnosed Breast Cancer Patients.
Asian Pac J Cancer Prev
October 2024
Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan.
Background: For the initial staging of breast cancer (BC), 18FDG PET/CT is recommended by professional guidelines in stage III (except T3N1) and inflammatory BC (T4d) and optional when conventional imaging is equivocal or suspicious. However, growing evidence also supports its role in the staging of intermediate-risk groups (IIA, IIB, T3N1 of IA). This study aimed to compare the impact of 18FDG PET/CT with conventional imaging (CT-chest+abdomen+pelvis and bone scan; CT-CAP+BS) in staging, cost-effectiveness, and radiation exposure in the initial staging of BC.
View Article and Find Full Text PDFClinical and Cost-Effectiveness of Intraoperative Flap Perfusion Assessment With Indocyanine Green Fluorescence Angiography in Breast and Head and Neck Reconstructions: A Systematic Review and Meta-Analysis.
Microsurgery
November 2024
UCD Centre for Precision Surgery, University College Dublin, Dublin, Ireland.
Background: Indocyanine green fluorescence angiography (ICGFA) is gaining popularity for the assessment of reconstructive flap perfusion intraoperatively. This study analyses the literature with a focus on its clinical efficacy and cost-effectiveness across various plastic and reconstructive surgery procedures.
Methods: A systematic review was conducted in accordance with PRISMA guidelines on published studies in English comparing ICGFA with standard clinical assessment for flap perfusion.
Prevalence of unexpected intraoperative cultures (UPIC) in revision total knee arthroplasty (TKA) and risk of periprosthetic joint infection (PJI).
Arch Orthop Trauma Surg
December 2024
University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Article Synopsis
- The prevalence of unexpected positive intraoperative cultures (UPIC) in revision total knee arthroplasties (TKAs) is around 8.32%, with significant variability in reported findings across different studies due to differences in diagnostic methods for periprosthetic joint infection (PJI).
- A study analyzed 256 revision TKAs over 9 years, finding that 29.3% had at least one UPIC, and 13.28% were diagnosed as unsuspected PJI, leading to higher re-revision rates and treatment with antibiotics.
- After 24 months, a small percentage of patients (5.08%) required re-revision, with no reinfection cases linked to the same microorganisms, indicating that unsuspected PJ
Clinical Utility of Neurophysiologic Classification (and Declassification) of Myoclonus.
Mov Disord
December 2024
Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
Background: Movement clinical neurophysiology studies can distinguish myoclonus, tremor, and other jerky movements; however, there has been limited demonstration of their real-world clinical impact.
Objective: The aim was to investigate movement study utility in clarifying movement classification and guiding patient management.
Method: A retrospective study of myoclonus-related movement studies was performed.
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