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Insurance coverage and consistent pricing is needed for over-the-counter naloxone.
J Opioid Manag
January 2025
Division of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, Chapel Hill; South East Area Health Education Center, College of Nursing, University of North Carolina Wilmington, Wilmington, North Carolina. ORCID: https://orcid.org/0000-0002-7507-0631.
With the Food and Drug Administration's approval of the first over-the-counter naloxone nasal spray in 2023, it was expected that access to naloxone nasal spray would increase and that its cost would be reduced. However, the writers of this commentary found varying insurance coverage of naloxone during purchase attempts at local pharmacies. Failure to cover naloxone can reduce access and increase risk of overdose death.
View Article and Find Full Text PDFNasal absorption of oxycodone predicted using a novel computational fluid dynamics-physiologically based pharmacokinetic model.
J Control Release
January 2025
Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Oxycodone hydrochloride (HCl) extended release (ER) tablet is an abuse-deterrent formulation that uses a physical barrier to make it more difficult to crush tablets prior to abuse via various routes. A previously conducted in vivo pharmacokinetics (PK) study showed that particle size exhibited significant effects on PK. Here, a computational modeling study using a novel combined computational fluid dynamics and physiologically based PK model was applied to better understand the mechanisms that produce differences in PK according to particle size and formulation type for nasally insufflated oxycodone HCl immediate release (IR) and ER tablets.
View Article and Find Full Text PDFA nose for trouble: Tapentadol nasal spray use disorder associated nasal cartilage atrophy in a young male.
Asian J Psychiatr
December 2024
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, Pondicherry, India. Electronic address:
Examination of optical coherence tomography findings in patients with pregabalin use disorder.
PeerJ
November 2024
Department of Psychiatry, Institute of Health Sciences, İzmir Democracy University, İzmir, Turkey.
Background: Pregabalin abuse is a rapidly growing health problem worldwide, and little is known about the effects of prolonged high-dose use in patients with pregabalin use disorder.
Objective: In this study, the effects of pregabalin abuse on retinal layers were investigated in patients with pregabalin use disorder (PGUD).
Methods: This study included 35 controls and 34 patients with PGUD, according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria.
Towards the development of a portable device based on modified-voltammetric sensors for the detection of illicit drugs and seized samples.
Talanta
January 2025
Sensors and Biosensors Group, Department of Chemistry, Universitat Autònoma de Barcelona, Edifici Cn, 08193, Bellaterra, Barcelona, Spain. Electronic address:
Illicit drugs are a global burden, not only for society, but also for the various control authorities for which its rapid on-site detection remains a challenge. In this context, the potential of a voltammetric electronic tongue (ET) for the analysis of different drugs is evaluated herein. Concretely, the discrimination and identification of cocaine, heroin, 3,4-Methylenedioxymethamphetamine (MDMA), methamphetamine and ketamine in self-prepared and real samples were attempted.
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