Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-22-2507DOI Listing

Publication Analysis

Top Keywords

retraction reversible
4
reversible fourth-generation
4
fourth-generation egfr
4
egfr tyrosine
4
tyrosine kinase
4
kinase inhibitor
4
inhibitor obx02-011
4
obx02-011 overcomes
4
overcomes c797s-mediated
4
c797s-mediated resistance
4

Similar Publications

While there is ample research on the influence of retracted scientific publications on author reputation, less is known about how a health organization's retraction of scientific guidance can impact public perceptions of the organization. This study centers on the aerosol guidance retraction of the Centers for Disease Control and Prevention (CDC) in 2020. X/Twitter social media data were collected via ForSight from September 15 to October 8, 2020, with a machine learning algorithm specifically developed and used to detect sentiment toward the CDC.

View Article and Find Full Text PDF

Background: As part of an organ sparing strategy, a surgical local excision may be performed in patients with early-stage rectal cancer or following neoadjuvant (chemo)radiotherapy. In selected cases, a completion total mesorectal excision may be recommended which can be more complex because of the preceding local excision. A transanal approach to perform completion total mesorectal excision may offer an advantage through the better visualization of the surgical field in the distal rectum and less forceful retraction for exposure.

View Article and Find Full Text PDF

Aims: This study investigated the roles of lateral basal forebrain glial cell line-derived neurotrophic factor (GDNF) signaling and cholinergic neuron activity, apoptosis, and autophagy dysfunction in sleep deprivation-induced increased risk of chronic postsurgical pain (CPSP) in mice.

Methods: Sleep deprivation (6 h per day from -1 to 3 days postoperatively) was administered to mice receiving skin/muscle incision and retraction (SMIR) to determine whether perioperative sleep deprivation induces mechanical and thermal pain hypersensitivity, increases the risk of chronic pain, and causes changes of basal forebrain neurons activity (c-Fos immunostaining), apoptosis (cleaved Caspase-3 expression), autophagy (LC3 and p62 expression) and GDNF expression. Adeno-associated virus (AAV)-GDNF was microinjected into the basal forebrain to see whether increased GDNF expression could reverse sleep deprivation-induced changes in pain duration and cholinergic neuron apoptosis and autophagy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!