A multiselective Diels-Alder (DA) reaction of α-arylacroleins with cyclopentadiene using BBr-assisted chiral BINOL-derived phosphoric acid catalysts has been developed. This unusual - and enantioselective DA reaction can be multicontrolled by the chiral cavity of the -formed acid-base cooperative catalysts, in particular, suppressing the competitive hetero Diels-Alder (HDA) reaction effectively.
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| http://dx.doi.org/10.1021/acs.orglett.2c02747 | DOI Listing |
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