AI Article Synopsis
- Single component organic ferroelectrics, specifically spirooxazacamphorsultam derivatives, demonstrate notable ferroelectric and piezoelectric properties at temperatures below their melting point.
- The ferroelectricity observed is quantified at 2.2 μC/cm and piezoelectricity at 10 pC/N.
- Additionally, these materials have a low acoustic impedance of 2.7 × 10 kg/s·m, making them compatible with biological tissues.
Article Abstract
Single component organic ferroelectrics of spirooxazacamphorsultam derivatives, 1- and 1-, exhibit well-defined ferroelectricity ( = 2.2 μC cm) and piezoelectricity ( = 10 pC N) below their melting point. More importantly, they possess a low acoustic impedance value of 2.7 × 10 kg s m, which is well-matched with body tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2cc03881a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Drug Development.
Alzheimers Dement
December 2024
Sanford burnham prebys medical discovery institute, San Diego, CA, USA.
Background: A pathological hallmark of Alzheimer's disease (AD) is the accumulation of amyloid-beta peptide (Aß). Potential treatments targeting Aß production such as γ-secretase inhibitors have had limited success. A promising alternative approach involves addressing early synaptic dysfunction by modulating molecules like striatal-enriched protein tyrosine phosphatase (STEP), whose levels and activity are upregulated by Aß.
View Article and Find Full Text PDFCerebral beta-amyloid accumulation is the key initiator of Alzheimer's disease (AD) pathology. Most familial early-onset AD mutations in the APP, PSEN1/2 genes increase the ratio of Abeta42:Abeta40, which drives beta-amyloid accumulation in the brain. In 2001, the late Steve Wagner, Maria Kounnas, and I directed an agnostic high-throughput screen for compounds that would reverse the Abeta42:Abeta40, ratio, and discovered the first non-NSAID (second generation) gamma secretase modulators (GSM) at TorreyPines Therapeutics.
View Article and Find Full Text PDFEnhanced Near-Infrared Fluorescence Emission near a Graphene-Metal Hybrid Structure.
J Phys Chem A
January 2025
Key Lab of Advanced Transducers and Intelligent Control System, Ministry of Education and Shanxi Province, College of Physics and Optoelectronics, Taiyuan University of Technology, Taiyuan 030024, China.
Plasmon resonance plays an important role in improving the detection of biomolecules, and it is one of the focuses of research to use metal plasmon resonance to achieve fluorescence enhancement and to improve detection sensitivity. However, the problems of nondynamic tuning and fluorescence quenching of metal plasmon resonance need to be solved. Graphene surface plasmon resonance can be dynamically controlled, and the graphene adsorption of fluorescent molecules can avoid fluorescence quenching and greatly improve the fluorescence emission intensity.
View Article and Find Full Text PDFNew Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.
Mini Rev Med Chem
January 2025
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia.
Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas.
View Article and Find Full Text PDFTropos Diphenylmethane-Based Phosphine-Phosphoramidite Ligands: Design, Synthesis, and Application in Catalytic Asymmetric Hydrogenation.
Org Lett
January 2025
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
A series of chiral hybrid diphosphorus ligands incorporating a conformationally flexible tropos diphenylmethane-based phosphoramidite unit have been developed and evaluated in the Rh-catalyzed asymmetric hydrogenation of 2-(1-arylvinyl)anilides and α-enamides, leading to up to >99% yield and 99% enantiomeric excess. Preliminary results from comparative studies showcased the extraordinary catalytic performance of these chiral tropos phosphine-phosphoramidite ligands, with a competency essentially superior to those of well-established ligands with a regular rigid backbone.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!