AI Article Synopsis
- Several types of laminoplasty spacers, including a 3D scaffold made of polylactic acid (PLA) with alginate/hydroxyapatite and mesenchymal stem cells, were tested for their ability to fill bone gaps in rabbits.
- The study found no inflammation or necrosis in most rabbit models, indicating good biocompatibility and tissue integration of the synthetic scaffold compared to traditional autografts.
- The results suggest that further studies in humans are warranted to explore the potential of these synthetic scaffolds for treating bone defects.
Article Abstract
Several types of laminoplasty spacer have been used to fill bone gaps and maintain a widened canal. A 3D scaffold can be used as an alternative spacer to minimize the risk observed in allografts or autografts. This study aims to evaluate the in vivo biocompatibility and tissue−scaffold integration of a polylactic acid (PLA) scaffold with the addition of alginate/hydroxyapatite (HA) and mesenchymal stem cell (MSc) injections. This is an experimental study with a pretest and post-test control group design. A total of 15 laminoplasty rabbit models were divided into five groups with variations in the autograft, PLA, HA/alginate, and MSc scaffold. In general, there were no signs of inflammation in most samples (47%), and there were no samples with areas of necrosis. There were no significant differences in the histopathological results and microstructural assessment between the five groups. This demonstrates that the synthetic scaffolds that we used had a similar tissue reaction and tissue integration profile as the autograft (p > 0.05). We recommend further translational studies in humans so that this biocompatible fabricated scaffold can be used to fill bone defects.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416571 | PMC |
| http://dx.doi.org/10.3390/polym14163292 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Graphene-Based Coating 3D Printing Process on the Remanence and Corrosion of Sintered NdFeB Magnets.
3D Print Addit Manuf
December 2024
Materials Science and Technology Center (CCTM), Nuclear, and Energy Research Institute (IPEN), University of São Paulo (USP), São Paulo, São Paulo, Brazil.
This study describes a 3D fused deposition modeling (FDM) printing process using a graphene-impregnated polylactic acid (G-PLA) filament to create a new type of rigid, plastic, nonconductive, and anticorrosion layer. Therefore, the possibility of 3D printing a plastic layer using FDM methods is demonstrated herein. A commercial magnet such as N35 NdFeB can be used to produce an efficient shielding film by additive manufacturing.
View Article and Find Full Text PDFA new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.
Sci Rep
December 2024
Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
This paper introduces an evidence-based, design-of-experiments (DoE) approach to analyze and optimize drug delivery systems, ensuring that release aligns with the therapeutic window of the medication. First, the effective factors and release data of the system are extracted from the literature and meta-analytically undergo regression modeling. Then, the interaction and correlation of the factors to each other and the release amount are quantitatively assessed.
View Article and Find Full Text PDFThe role of biodegradable plastics in lignite anaerobic digestion: Changes of organics transformation and metabolic pathway.
Bioresour Technol
December 2024
School of Energy Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China. Electronic address:
Biodegradable plastics (BPs) and lignite, both rich in organic matter, present significant challenges for efficient conversion into clean energy. This study examined the anaerobic co-digestion of BPs and lignite under controlled laboratory conditions. The results demonstrated that the co-digestion of polylactic acid (PLA) and lignite (at a 1:2 mass ratio, with 5 g PLA and 10 g lignite as the model system) rapidly acclimated to the anaerobic environment, enhancing cumulative biogas production by 57 % compared to the mono-digestion of lignite alone.
View Article and Find Full Text PDFEnhanced flame retardancy and accelerated degradation of polylactic acid using a chitosan-based additive with phosphorus and zinc.
Int J Biol Macromol
December 2024
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
Polylactic acid (PLA) is a bio-recyclable plastic, but its high flammability limits broader applications. Here, a novel flame retardant (Zn-CHP) is synthesized from chitosan (CH), diethylenetriaminepenta (methylenephosphonic) acid (DTPMP), and ZnCl₂ using a simple, solvent-free process. The Zn-CHP additive is melt-blended with PLA, achieving excellent flame retardancy at just 2 wt% loading.
View Article and Find Full Text PDFTranscription-metabolism analysis of various signal transduction pathways in Brassica chinensis L. exposed to PLA-MPs.
J Hazard Mater
December 2024
College of Environmental Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China. Electronic address:
Biodegradable plastics, regarded as an ideal substitute for traditional plastics, are increasingly utilized across various industries. However, due to their unique degradation properties, they can generate microplastics (MPs) at a faster rate, potentially posing a threat to plant development. This study employed transcriptomics and metabolomics to investigate the effects of polylactic acid microplastics (PLA-MPs) on the physiological and biochemical characteristics of Brassica chinensis L.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!